In praise of povidone-iodine application in ophthalmology

IF 5.1 2区 医学 Q1 OPHTHALMOLOGY
Mohammad Soleimani , Ali A. Haydar , Kasra Cheraqpour , Haniyeh Zeidabadinejad , Amirreza Esfandiari , Niloofarsadaat Eshaghhosseiny , Alireza Shahmohammadi , Soraya Banz , Ali R. Djalilian
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引用次数: 0

Abstract

Polyvinyl pyrrolidone or povidone-iodine (PVP-I) is a water-soluble complex formed by the combination of iodine and a water-soluble polymer, polyvinyl pyrrolidone. This complex exerts bactericidal, fungicidal, and virucidal action by gradually releasing free iodine at the site of application to react with pathogens. In ophthalmology, PVP-I is used as a disinfectant and antiseptic agent for preoperative preparation of the skin and mucous membranes and for treating contaminated wounds. PVP-I has been shown to reduce effectively the risk of endophthalmitis in various ocular procedures, including cataract surgery and intravitreal injections; however, it has also been used in the treatment of conjunctivitis, keratitis, and endophthalmitis, with promising results especially in low-resource situations. PVP-I has been associated with complications such as postoperative eye pain, persistent corneal epithelial defects, ocular inflammation, and an attendant risk of keratitis. In cases of poor PVP-I tolerance, applying PVP-I at lower concentrations or using alternative antiseptics such as chlorhexidine should be considered. We provide an update on the efficacy of PVP-I in the prophylaxis and treatment of conjunctivitis, keratitis, and endophthalmitis and a comprehensive analysis of the current literature regarding the use of PVP-I in the management of these ocular conditions. Also, PVP-I-related adverse effects and toxicities and its alternatives are discussed. The goal is to present a thorough evaluation of the available evidence and to offer practical recommendations for clinicians regarding the therapeutic usage of PVP-I in ophthalmology.

赞扬聚维酮碘在眼科的应用。
聚乙烯吡咯烷酮或聚维酮碘(PVP-I)是一种水溶性复合物,由碘和水溶性聚合物聚乙烯吡咯烷醇的组合形成。这种复合物通过在施用部位逐渐释放游离碘与病原体反应而发挥杀菌、杀菌和杀病毒作用。在眼科,PVP-I被用作消毒剂和防腐剂,用于皮肤和粘膜的术前准备以及治疗受污染的伤口。PVP-I已被证明在各种眼科手术中有效降低眼内炎的风险,包括白内障手术和玻璃体内注射;然而,它也被用于治疗结膜炎、角膜炎和眼内炎,特别是在资源不足的情况下,效果很好。PVP-I与并发症有关,如术后眼部疼痛、持续性角膜上皮缺损、眼部炎症和随之而来的角膜炎风险。在PVP-I耐受性差的情况下,应考虑使用较低浓度的PVP-I或使用氯己定等替代防腐剂。我们提供了PVP-I在预防和治疗结膜炎、角膜炎和眼内炎方面的最新疗效,并对目前关于PVP-I用于治疗这些眼部疾病的文献进行了全面分析。此外,还讨论了PVP-I相关的不良反应和毒性及其替代品。目的是对现有证据进行全面评估,并为临床医生提供有关PVP-I在眼科治疗中使用的实用建议。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Survey of ophthalmology
Survey of ophthalmology 医学-眼科学
CiteScore
10.30
自引率
2.00%
发文量
138
审稿时长
14.8 weeks
期刊介绍: Survey of Ophthalmology is a clinically oriented review journal designed to keep ophthalmologists up to date. Comprehensive major review articles, written by experts and stringently refereed, integrate the literature on subjects selected for their clinical importance. Survey also includes feature articles, section reviews, book reviews, and abstracts.
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