Renal osteodystrophy and clinical outcomes: a prospective cohort study.

IF 1.3 Q3 UROLOGY & NEPHROLOGY

Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia Pub Date : 2024-04-01 DOI:10.1590/2175-8239-JBN-2023-0119en

Cinthia Esbrile Moraes Carbonara, Joaquim Barreto, Noemi Angelica Vieira Roza, KélciaRosana da Silva Quadros, Luciene Machado Dos Reis, Aluízio Barbosa de Carvalho, Andrei C Sposito, Vanda Jorgetti, Rodrigo Bueno de Oliveira

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Abstract

Introduction: Renal osteodystrophy (ROD) refers to a group of bone morphological patterns that derive from distinct pathophysiological mechanisms. Whether the ROD subtypes influence long-term outcomes is unknown. Our objective was to explore the relationship between ROD and clinical outcomes.

Methods: This study is a subanalysis of the Brazilian Registry of Bone Biopsies (REBRABO). Samples from individual patients were classified as having osteitis fibrosa (OF), mixed uremic osteodystrophy (MUO), adynamic bone disease (ABD), osteomalacia (OM), normal/minor alterations, and according to turnover/mineralization/volume (TMV) system. Patients were followed for 3.4 yrs. Clinical outcomes were: bone fractures, hospitalization, major adverse cardiovascular events (MACE), and death.

Results: We enrolled 275 participants, of which 248 (90%) were on dialysis. At follow-up, 28 bone fractures, 97 hospitalizations, 44 MACE, and 70 deaths were recorded. ROD subtypes were not related to outcomes.

Conclusion: The incidence of clinical outcomes did not differ between the types of ROD.

查看原文本刊更多论文

肾性骨营养不良与临床结果：一项前瞻性队列研究。

引言：肾性骨营养不良（ROD）是指一组来源于不同病理生理机制的骨形态模式。ROD亚型是否影响长期结果尚不清楚。我们的目的是探讨ROD与临床结果之间的关系。方法：本研究是对巴西骨活检注册中心（REBRABO）的亚分析。来自个体患者的样本被分类为患有纤维性骨炎（OF）、混合性尿毒症性骨营养不良（MUO）、动力性骨病（ABD）、骨软化症（OM）、正常/轻微改变，并根据周转/矿化/体积（TMV）系统。患者随访3.4年。临床结果为：骨折、住院、主要心血管不良事件（MACE）和死亡。结果：我们招募了275名参与者，其中248人（90%）正在接受透析。在随访中，记录了28例骨折、97例住院、44例MACE和70例死亡。ROD亚型与结果无关。结论：不同类型ROD的临床结果发生率没有差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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