The alkynyl-containing compounds from mushrooms and their biological activities

IF 4.8 3区化学 Q1 CHEMISTRY, MEDICINAL

Natural Products and Bioprospecting Pub Date : 2023-11-10 DOI:10.1007/s13659-023-00416-w

Ji-shuang Qi, Yingce Duan, Zhao-chen Li, Jin-ming Gao, Jianzhao Qi, Chengwei Liu

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Abstract

Mushrooms have been utilized by humans for thousands of years due to their medicinal and nutritional properties. They are a crucial natural source of bioactive secondary metabolites, and recent advancements have led to the isolation of several alkynyl-containing compounds with potential medicinal uses. Despite their relatively low abundance, naturally occurring alkynyl compounds have attracted considerable attention due to their high reactivity. Bioactivity studies have shown that alkynyl compounds exhibit significant biological and pharmacological activities, including antitumor, antibacterial, antifungal, insecticidal, phototoxic, HIV-inhibitory, and immunosuppressive properties. This review systematically compiles 213 alkynyl-containing bioactive compounds isolated from mushrooms since 1947 and summarizes their diverse biological activities, focusing mainly on cytotoxicity and anticancer effects. This review serves as a detailed and comprehensive reference for the chemical structures and bioactivity of alkynyl-containing secondary metabolites from mushrooms. Moreover, it provides theoretical support for the development of chemical constituents containing alkynyl compounds in mushrooms based on academic research and theory.

Graphical Abstract

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蘑菇中的含炔基化合物及其生物活性。

蘑菇因其药用和营养特性而被人类利用了数千年。它们是生物活性次级代谢产物的重要天然来源，最近的进展导致分离出几种具有潜在药用价值的含炔基化合物。尽管它们的丰度相对较低，但天然存在的炔基化合物由于其高反应性而引起了相当大的关注。生物活性研究表明，炔基化合物具有显著的生物学和药理学活性，包括抗肿瘤、抗菌、抗真菌、杀虫、光毒性、HIV抑制和免疫抑制特性。这篇综述系统地汇编了自1947年以来从蘑菇中分离出的213种含炔基的生物活性化合物，并总结了它们的多种生物活性，主要集中在细胞毒性和抗癌作用上。这篇综述为蘑菇含炔基次生代谢产物的化学结构和生物活性提供了详细而全面的参考。此外，它还为基于学术研究和理论开发蘑菇中含炔基化合物的化学成分提供了理论支持。

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来源期刊

Natural Products and Bioprospecting CHEMISTRY, MEDICINAL-

CiteScore

8.30

自引率

2.10%

发文量

审稿时长

13 weeks

期刊介绍： Natural Products and Bioprospecting serves as an international forum for essential research on natural products and focuses on, but is not limited to, the following aspects: Natural products: isolation and structure elucidation Natural products: synthesis Biological evaluation of biologically active natural products Bioorganic and medicinal chemistry Biosynthesis and microbiological transformation Fermentation and plant tissue cultures Bioprospecting of natural products from natural resources All research articles published in this journal have undergone rigorous peer review. In addition to original research articles, Natural Products and Bioprospecting publishes reviews and short communications, aiming to rapidly disseminate the research results of timely interest, and comprehensive reviews of emerging topics in all the areas of natural products. It is also an open access journal, which provides free access to its articles to anyone, anywhere.