Synthesis, crystal structure and antimicrobial activities of two silver(I) complexes based on bis(pyrazole) and carboxylic acid co-ligands

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-10-16 DOI:10.1007/s11243-023-00556-5

Hong Yang, Heng-Hui Zhang, Chang-Qing Li, Li-Jun Guo, Miao Yang, Tuo-Ping Hu

{"title":"Synthesis, crystal structure and antimicrobial activities of two silver(I) complexes based on bis(pyrazole) and carboxylic acid co-ligands","authors":"Hong Yang, Heng-Hui Zhang, Chang-Qing Li, Li-Jun Guo, Miao Yang, Tuo-Ping Hu","doi":"10.1007/s11243-023-00556-5","DOIUrl":null,"url":null,"abstract":"<div>Two dinuclear and centrosymmetric silver-containing complexes, namely [Ag2(3,5-dmpz)2(3,5-dmpz methanol)2(tbtc)] (1) and [Ag2(3,5-dmpz)2(3,5-dmpz methanol)2(dbtc)] (2) (3,5-dmpz: dimethylpyrazole; 3,5-dmpz methanol: 3,5-dimethylpyrazole methanol; H2tbtc: tetrabromoterephthalic acid; H2dbtc: 2,5-dibromoterephthalic acid), were prepared and characterized. X-ray crystallographic data of 1 and 2 revealed that trigonal environment of the Ag ions has a “compressed Y’s” geometry. The antimicrobial activity of 1 and 2 was tested against the Gram-positive, Gram-negative bacteria and fungus, displaying the better inhibiting activity than the individual AgNO3 and 3,5-dimethylpyrazole, especially for Candida albicans (IC50 2.5 ± 0.1 mg mL −1 and 2.8 ± 0.2 mg mL−1). The quantified IC50 values displayed that complexes 1 and 2 were more effective against fungus than the Gram-negative bacteria and Gram-positive bacteria.</div>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s11243-023-00556-5","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

Two dinuclear and centrosymmetric silver-containing complexes, namely [Ag₂(3,5-dmpz)₂(3,5-dmpz methanol)₂(tbtc)] (1) and [Ag₂(3,5-dmpz)₂(3,5-dmpz methanol)₂(dbtc)] (2) (3,5-dmpz: dimethylpyrazole; 3,5-dmpz methanol: 3,5-dimethylpyrazole methanol; H₂tbtc: tetrabromoterephthalic acid; H₂dbtc: 2,5-dibromoterephthalic acid), were prepared and characterized. X-ray crystallographic data of 1 and 2 revealed that trigonal environment of the Ag ions has a “compressed Y’s” geometry. The antimicrobial activity of 1 and 2 was tested against the Gram-positive, Gram-negative bacteria and fungus, displaying the better inhibiting activity than the individual AgNO₃ and 3,5-dimethylpyrazole, especially for Candida albicans (IC₅₀ 2.5 ± 0.1 mg mL ⁻¹ and 2.8 ± 0.2 mg mL⁻¹). The quantified IC₅₀ values displayed that complexes 1 and 2 were more effective against fungus than the Gram-negative bacteria and Gram-positive bacteria.

Abstract Image

查看原文本刊更多论文

两种基于双（吡唑）和羧酸共配体的银（I）配合物的合成、晶体结构和抗菌活性

制备并表征了两种双核且中心对称的含银配合物，即[Ag2（3,5-dmpz）2（3,5-dmpz甲醇）2（tbtc）]（1）和[Ag2。1和2的X射线晶体学数据表明，Ag离子的三角环境具有“压缩的Y”几何结构。1和2对革兰氏阳性菌、革兰氏阴性菌和真菌的抗菌活性测试，显示出比单独的AgNO3和3，5-二甲基吡唑更好的抑制活性，尤其是对白色念珠菌的抑制活性（IC50 2.5 ± 0.1毫克毫升 −1和2.8 ± 0.2 mg mL−1）。定量的IC50值显示复合物1和2比革兰氏阴性菌和革兰氏阳性菌对真菌更有效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.