External stimulation-controlled dynamic DNA devices for biosensing and biomedical applications

IF 10.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Science China Chemistry Pub Date : 2023-10-07 DOI:10.1007/s11426-023-1783-5

Wei Xu, Feifei Hu, Jiajing Li, Jinhua Shang, Xiaoqing Liu, Yan Zeng, Qiong Wu, Fuan Wang

{"title":"External stimulation-controlled dynamic DNA devices for biosensing and biomedical applications","authors":"Wei Xu, Feifei Hu, Jiajing Li, Jinhua Shang, Xiaoqing Liu, Yan Zeng, Qiong Wu, Fuan Wang","doi":"10.1007/s11426-023-1783-5","DOIUrl":null,"url":null,"abstract":"<div><p>DNA devices that can recognize molecular inputs and transform them into functional outputs in an autonomous manner have been actively pursued as versatile toolkits for controlled nanofabrication, molecular network regulation, biosensing and cellular function modulation. The introduction of external stimuli-responsive units not only ensures the programmability and functionality of DNA devices themselves, but also confers rapid, remote and reversible dynamic regulation capabilities. This facilitates on-demand activation and expands the application scope of dynamic DNA devices. Herein, an overview of recent advances in the construction of stimuli-responsive DNA devices that respond to different exogenous triggers, including physical stimuli (<i>e.g.</i>, light, thermal, magnetic field, and electric field), chemical stimuli (<i>e.g.</i>, supermolecules, pH, redox, and metal ions), and biological cues (<i>e.g.</i>, protein, biomolecule, and nucleic acid), and their controllable nanofabrication and biomedical application have been provided. The current challenges and potential solutions of these externally responsive DNA devices for their future advancements in this emerging field are also discussed.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":772,"journal":{"name":"Science China Chemistry","volume":"66 11","pages":"3105 - 3115"},"PeriodicalIF":10.4000,"publicationDate":"2023-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Science China Chemistry","FirstCategoryId":"1","ListUrlMain":"https://link.springer.com/article/10.1007/s11426-023-1783-5","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

DNA devices that can recognize molecular inputs and transform them into functional outputs in an autonomous manner have been actively pursued as versatile toolkits for controlled nanofabrication, molecular network regulation, biosensing and cellular function modulation. The introduction of external stimuli-responsive units not only ensures the programmability and functionality of DNA devices themselves, but also confers rapid, remote and reversible dynamic regulation capabilities. This facilitates on-demand activation and expands the application scope of dynamic DNA devices. Herein, an overview of recent advances in the construction of stimuli-responsive DNA devices that respond to different exogenous triggers, including physical stimuli (e.g., light, thermal, magnetic field, and electric field), chemical stimuli (e.g., supermolecules, pH, redox, and metal ions), and biological cues (e.g., protein, biomolecule, and nucleic acid), and their controllable nanofabrication and biomedical application have been provided. The current challenges and potential solutions of these externally responsive DNA devices for their future advancements in this emerging field are also discussed.

查看原文本刊更多论文

用于生物传感和生物医学应用的外部刺激控制的动态DNA设备

能够识别分子输入并以自主方式将其转化为功能输出的DNA设备已被积极作为控制纳米制造、分子网络调节、生物传感和细胞功能调节的通用工具包。外部刺激响应单元的引入不仅确保了DNA设备本身的可编程性和功能性，还赋予了快速、远程和可逆的动态调节能力。这便于按需激活，并扩大了动态DNA设备的应用范围。在此，概述了构建对不同外源触发因素做出反应的刺激响应性DNA装置的最新进展，包括物理刺激（如光、热、磁场和电场）、化学刺激（如超分子、pH、氧化还原和金属离子）和生物线索（如蛋白质、生物分子和核酸），并提供了它们的可控纳米制造和生物医学应用。还讨论了这些外部响应DNA设备在这一新兴领域的未来发展面临的挑战和潜在解决方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Science China Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

14.40

自引率

7.30%

发文量

3787

审稿时长

2.2 months

期刊介绍： Science China Chemistry, co-sponsored by the Chinese Academy of Sciences and the National Natural Science Foundation of China and published by Science China Press, publishes high-quality original research in both basic and applied chemistry. Indexed by Science Citation Index, it is a premier academic journal in the field. Categories of articles include: Highlights. Brief summaries and scholarly comments on recent research achievements in any field of chemistry. Perspectives. Concise reports on thelatest chemistry trends of interest to scientists worldwide, including discussions of research breakthroughs and interpretations of important science and funding policies. Reviews. In-depth summaries of representative results and achievements of the past 5–10 years in selected topics based on or closely related to the research expertise of the authors, providing a thorough assessment of the significance, current status, and future research directions of the field.