Metabolic syndrome-related cognitive impairment with white matter hyperintensities and functional network analysis

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Obesity Pub Date : 2023-09-19 DOI:10.1002/oby.23873

Wenhui Zheng, Xia Zhou, Jiabin Yin, Han Liu, Wenwen Yin, Wei Zhang, Xiaoqun Zhu, Zhongwu Sun

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引用次数: 1

Abstract

Objective

This study aimed to explore the relationship between white matter hyperintensities (WMHs) and cognitive impairment related to metabolic syndrome (MetS) and the underlying neural network mechanisms.

Methods

This cross-sectional study included 50 participants with MetS and WMHs (MetS-WMHs), 45 with MetS without WMHs, and 50 control participants. All participants underwent resting-state functional magnetic resonance imaging and a detailed cognitive evaluation. A graph theory analysis based on resting-state functional magnetic resonance imaging was conducted to calculate functional network properties. A mediation analysis was conducted to determine the relationship between WMHs and MetS-related cognitive impairment.

Results

Compared with the control group, the participants in the MetS-WMHs group displayed lower global efficiency, local efficiency, and nodal efficiency, mainly located in the regions of the salience network. Furthermore, a significant correlation was observed between functional network efficiency and cognitive performance. Mediation analysis indicated that WMHs served as a mediating variable between MetS and cognitive decline, affecting attention/executive function, language, and global cognitive function.

Conclusions

WMHs mediated the association between MetS and cognitive function, with a decline in the efficiency of functional brain networks being a probable neural mechanism.

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代谢综合征相关的认知障碍与白质高信号和功能网络分析

目的探讨脑白质高信号(WMHs)与代谢综合征(MetS)相关认知功能障碍的关系及其神经网络机制。方法本横断面研究包括50例met合并WMHs (MetS-WMHs)， 45例met合并WMHs, 50例对照。所有参与者都接受了静息状态功能磁共振成像和详细的认知评估。采用基于静息状态功能磁共振成像的图论分析方法计算功能网络性质。通过中介分析来确定wmh与mets相关的认知障碍之间的关系。结果与对照组相比，MetS-WMHs组的整体效率、局部效率和节点效率均较低，节点效率主要位于显著性网络区域。此外，功能性网络效率与认知表现之间存在显著的相关性。中介分析表明，WMHs是MetS与认知功能下降之间的中介变量，影响注意/执行功能、语言和整体认知功能。结论wmh介导了MetS与认知功能之间的关联，脑功能网络效率的下降可能是其神经机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity 医学-内分泌学与代谢

CiteScore

11.70

自引率

1.40%

发文量

261

审稿时长

2-4 weeks

期刊介绍： Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.