Effects of silica surface modification with silane and poly(ethylene glycol) on flexural strength, protein-repellent, and antibacterial properties of acrylic dental nanocomposites

IF 4.6 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Dental Materials Pub Date : 2023-08-05 DOI:10.1016/j.dental.2023.07.010

Marzieh Kazemi , Amir H. Navarchian , Fatemeh Ahangaran

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引用次数: 0

Abstract

Objective

The main aim of the current work was to develop dental acrylic-based composites with protein-repellent and antibacterial properties by using surface-modified silica nanoparticles. The effects of surface modification of silica nanoparticles in protein-repellent and antibacterial activity and mechanical properties of dental composites including flexural strength, flexural modulus, and hardness were discussed.

Methods

The surface of silica nanoparticles was first chemically treated with 3-methacryloxypropyltrimethoxysilane (MPS) as a coupling agent and then with poly(ethylene glycol) (PEG) bonded to MPS. Dental acrylic-based composites were prepared with mass fractions of 10, 15, 20, 30, and 40 % of PEG-modified MPS-silica nanoparticles (PMS). The chemical surface modification of silica nanoparticles with MPS and PEG was confirmed by Fourier transform infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA).

Results

The dental composite containing 20 wt% PMS nanoparticles could reduce the protein adsorption by 28 % as compared with a composite containing 20 wt% MPS-modified silica. The antibacterial test indicated that the PMS nanoparticles can significantly reduce the adhesion of Streptococcus mutans and the biofilm formation on the surface of dental composites. It was found that the flexural strength increased by increasing the PMS nanoparticles from 0 to 20 wt% and then decreased by the incorporation of higher percentages of these nanoparticles. Also, with increasing the weight percentage of PMS nanoparticles, the elastic and the flexural modulus and the hardness of resin nanocomposites were increased.

Significance

In the current work, for the first time, dental resin composites containing PEG were prepared with excellent protein-repellent and antibacterial properties.

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硅烷和聚乙二醇改性二氧化硅表面对丙烯酸牙科纳米复合材料抗弯强度、拒蛋白和抗菌性能的影响

目的利用表面改性二氧化硅纳米颗粒制备具有蛋白驱避和抗菌性能的牙科丙烯酸基复合材料。讨论了纳米二氧化硅表面改性对牙用复合材料的拒蛋白、抗菌活性和抗弯强度、抗弯模量、硬度等力学性能的影响。方法先用3-甲基丙烯氧基丙基三甲氧基硅烷(MPS)作为偶联剂对纳米二氧化硅表面进行化学处理，然后用聚乙二醇(PEG)与MPS结合。分别以质量分数为10%、15%、20%、30%和40%的peg修饰mps -二氧化硅纳米颗粒(PMS)制备牙科丙烯酸基复合材料。通过傅里叶变换红外光谱(FTIR)和热重分析(TGA)证实了MPS和PEG对二氧化硅纳米颗粒表面的化学修饰作用。结果与含20 wt% mps修饰二氧化硅的复合材料相比，含20 wt% PMS纳米颗粒的牙科复合材料可减少28%的蛋白质吸附。抗菌实验表明，PMS纳米颗粒可以显著降低变形链球菌的粘附和口腔复合材料表面生物膜的形成。研究发现，将PMS纳米颗粒从0 wt%增加到20 wt%，抗弯强度增加，然后加入更高百分比的PMS纳米颗粒，抗弯强度降低。此外，随着PMS纳米颗粒质量百分比的增加，树脂纳米复合材料的弹性模量、弯曲模量和硬度均有所提高。意义本研究首次制备了含聚乙二醇的牙用树脂复合材料，具有优异的拒蛋白和抗菌性能。

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来源期刊

Dental Materials 工程技术-材料科学：生物材料

CiteScore

9.80

自引率

10.00%

发文量

290

审稿时长

67 days

期刊介绍： Dental Materials publishes original research, review articles, and short communications. Academy of Dental Materials members click here to register for free access to Dental Materials online. The principal aim of Dental Materials is to promote rapid communication of scientific information between academia, industry, and the dental practitioner. Original Manuscripts on clinical and laboratory research of basic and applied character which focus on the properties or performance of dental materials or the reaction of host tissues to materials are given priority publication. Other acceptable topics include application technology in clinical dentistry and dental laboratory technology. Comprehensive reviews and editorial commentaries on pertinent subjects will be considered.