Bipolar disorder and type 2 diabetes mellitus: A bidirectional relationship

IF 2.5 4区医学 Q2 PSYCHIATRY

European Journal of Psychiatry Pub Date : 2022-07-01 DOI:10.1016/j.ejpsy.2021.11.002

Dagmar Breznoscakova , Maria Pallayova

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引用次数: 2

Abstract

Background and objectives

Over the past few decades, research has revealed complex interactions between type 2 diabetes mellitus (T2DM) and a wide range of comorbid conditions. The present paper sought to examine the relationship between bipolar disorder and T2DM and clarify the clinical impact of therapeutic interventions, highlighting the interpretation and implications of recent literature reports.

Methods

The PubMed electronic database was searched for keywords “bipolar disorder” AND “diabetes” OR “glucose”. Based on this literature search, 15 meta-analyses/systematic reviews and numerous research studies were identified that examined interrelationships between bipolar disorders and T2DM.

Results

Patients with bipolar disorder have higher rates of T2DM compared to the general population. Further, type 2 diabetic patients with comorbid bipolar disorder often experience deteriorated long-term glucose control and increased cardiovascular morbidity and mortality. Recent literature suggests shared risk factors and underlying disease mechanisms. In addition, genetic factors, sedentary life-style, lack of exercise, increased simple carbohydrate intake, adverse effects of bipolar pharmacotherapy, and bipolar depressive symptoms phenomenology may affect glucose metabolism.

Conclusions

The observed bidirectional interaction merits screening for psychiatric disorders in T2DM and vice versa to allow for early detection and treatment of this at risk population. Selection of drugs with neutral metabolic effects and dose individualization hold significant promise for optimizing therapy with antipsychotic and antidiabetic agents.

查看原文本刊更多论文

双相情感障碍和2型糖尿病:双向关系

背景与目的在过去的几十年里，研究揭示了2型糖尿病（T2DM）与多种合并症之间的复杂相互作用。本文试图研究双相情感障碍与T2DM之间的关系，并阐明治疗干预的临床影响，强调最近文献报道的解释和意义。方法检索PubMed电子数据库中的关键词“双相情感障碍”、“糖尿病”或“葡萄糖”。基于这一文献检索，确定了15项荟萃分析/系统综述和大量研究，以检查双相情感障碍和T2DM之间的相互关系。结果与普通人群相比，双相情感疾病患者的T2DM发病率更高。此外，患有双相情感障碍的2型糖尿病患者的长期血糖控制经常恶化，心血管发病率和死亡率增加。最近的文献表明，共同的风险因素和潜在的疾病机制。此外，遗传因素、久坐的生活方式、缺乏锻炼、简单碳水化合物摄入增加、双相药物治疗的不良影响以及双相抑郁症状现象可能会影响葡萄糖代谢。结论观察到的双向相互作用有助于筛查T2DM患者的精神障碍，反之亦然，以便早期发现和治疗这一高危人群。选择具有中性代谢作用和剂量个体化的药物对优化抗精神病药物和抗糖尿病药物的治疗具有重要前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Psychiatry PSYCHIATRY-

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

43 days

期刊介绍： The European journal of psychiatry is a quarterly publication founded in 1986 and directed by Professor Seva until his death in 2004. It was originally intended to report “the scientific activity of European psychiatrists” and “to bring about a greater degree of communication” among them. However, “since scientific knowledge has no geographical or cultural boundaries, is open to contributions from all over the world”. These principles are maintained in the new stage of the journal, now expanded with the help of an American editor.