Efectos adversos relacionados con la administración de norepinefrina por accesos venosos periféricos cortos: una revisión de alcance

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-10-01 DOI:10.1016/j.enfi.2022.09.001

J. García-Uribe RN, MSc , D. Lopera-Jaramillo RN, MSc , J. Gutiérrez-Vargas Bióloga, PhD , A. Arteaga-Noriega RN, MSc, PhD , O.A. Bedoya RN, MSc, PhD

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Abstract

Peripheral administration of norepinephrine is restricted due to the association of extravasation with tissue necrosis.

Method

scoping review with the objective of describing the adverse effects related to the administration of norepinephrine through short peripheral venous access and the characteristics of drug administration in patients hospitalized in ICU, surgery, and emergency services.

Results

12 studies with heterogeneous characteristics by size and type of population were included. The proportion of complications associated with peripheral norepinephrine administration was less than 12% in observational studies and it was less than 2% in those that used doses less than 0.13 μg/kg/min, and concentrations less than 22.3 μg/ml. The main associated complication was extravasation and there were no cases of tissue necrosis at the venipuncture site, some extravasation cases were treated with phentolamine, terbutaline or topical nitroglycerin. The drug administration time ranged between 1-528 hours with a weighted mean of 2.78 h.

Conclusion

The main adverse effect was extravasation, no additional complications occurred, phentolamine and terbutaline seem to be useful, and its availability is a necessity. It is essential for the nursing staff to carry out a close assessment and comprehensive care in patients receiving norepinephrine by peripheral route.

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去甲肾上腺素给药对短外周静脉通路的不良反应:范围综述

由于外渗与组织坏死相关，去甲肾上腺素的外周给药受到限制。方法应对策略综述，目的是描述通过短外周静脉途径给药去甲肾上腺素的不良反应，以及在ICU、手术和急救服务中住院患者的给药特点。结果纳入了12项按人口规模和类型具有异质性特征的研究。在观察性研究中，与外周去甲肾上腺素给药相关的并发症比例低于12%，在使用剂量低于0.13μg/kg/min和浓度低于22.3μg/ml的患者中，并发症比例低于2%。主要相关并发症是外渗，静脉穿刺部位没有组织坏死的病例，部分外渗病例采用酚妥拉明、特布他林或局部硝酸甘油治疗。给药时间为1-528小时，加权平均值为2.78小时。结论主要不良反应为外渗，没有出现其他并发症，酚妥拉明和特布他林似乎是有用的，其可用性是必要的。护理人员必须对通过外周途径接受去甲肾上腺素治疗的患者进行密切评估和全面护理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.