Management of paediatric benign bone tumour

Abstract

Primary tumours of bone are a diverse group of lesions that range from benign to malignant neoplasms. While primary benign bone tumours are more prevalent than malignancies in children malignant bone tumours are the seventh most common type of malignancies in children, accounting for roughly 3%–5% of cancers between the ages of 0 and 14 years. Whilst certain aspects of benign bone tumours can be challenging to diagnose and differentiate recent research employing advanced molecular and genetic methodologies has expanded our understanding. This in combination with the neoplasm cell architecture establishes the diagnosis. Whilst recent introduction of massively parallel sequencing-based methods has opened new opportunities for diagnosing bone cancers, the diagnosis of bone lesions is reliant on diagnostic imaging and multidisciplinary team (MDT) discussion. While management of benign tumours is dependent on the diagnosis and clinical features in most cases it requires simple curettage and complete excision.