Endocrine biomarkers related to sleep-wake cycle and sleep disturbances in patients with bipolar disorder: A systematic review

IF 2.5 4区医学 Q2 PSYCHIATRY

European Journal of Psychiatry Pub Date : 2022-10-01 DOI:10.1016/j.ejpsy.2022.04.004

Leticia González-Blanco , Carlota Moya-Lacasa , Sara Jiménez-Fernández , Clara Martínez-Cao , Mercedes Valtueña-García , Francesco Dal Santo , M. Paz García-Portilla , Luis Gutiérrez-Rojas

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Abstract

Background and objectives

Sleep and circadian disturbances have been widely studied in patients with bipolar disorder. However, there is no clear evidence about the role of peripheral biomarkers of the circadian cycle in this population. This systematic review aims to identify potential endocrine blood biomarkers of circadian rhythms and study their relationship with sleep problems in these patients.

Methods

An electronic search was performed of PubMed and PsycINFO databases. It included articles about the topic from 1991 through 2021. The search strategy was: ("peripheral biomarkers" OR "biological markers" OR biomarker OR cortisol OR melatonin OR orexin OR hypocretin) AND (blood OR serum OR plasma) AND (“sleep-wake” OR "circadian rhythm" OR sleep OR insomnia) AND "bipolar."

Results

After excluding duplicates, 92 records were obtained. Only 5 studies met the inclusion criteria (n=499; bipolar disorder=125; unipolar depression=148; schizophrenia=80; controls=146). The endocrine parameters analyzed were: cortisol (3 studies), melatonin (1 study), and orexin-A (1 study). Overall, no significant associations were detected between these biomarkers and sleep disturbances, assessed with subjective (psychometric evaluation) and/or objective (polysomnography) measures.

Conclusion

This review highlights the lack of studies exploring the role of endocrine biomarkers related to circadian function in the pathophysiology of sleep disturbances in bipolar disorder.

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双相情感障碍患者睡眠-觉醒周期和睡眠障碍相关的内分泌生物标志物:一项系统综述

背景与目的双相情感障碍患者的睡眠和昼夜节律紊乱已被广泛研究。然而，没有明确的证据表明昼夜节律周期的外围生物标志物在该人群中的作用。这项系统综述旨在确定昼夜节律的潜在内分泌血液生物标志物，并研究它们与这些患者睡眠问题的关系。方法对PubMed和PsycINFO数据库进行电子检索。其中包括1991年至2021年关于该主题的文章。搜索策略为：（“外周生物标志物”或“生物标志物“或生物标志物或皮质醇或褪黑素或食欲素或下丘脑）AND（血液或血清或血浆）AND（“睡眠-觉醒”或“昼夜节律”或睡眠或失眠）AND“双相性”。只有5项研究符合纳入标准（n=499；双相情感障碍=125；单极性抑郁症=148；精神分裂症=80；对照组=146）。分析的内分泌参数为：皮质醇（3项研究）、褪黑激素（1项研究）和食欲素-A（1项调查）。总体而言，通过主观（心理测量评估）和/或客观（多导睡眠图）测量评估，这些生物标志物与睡眠障碍之间没有发现显著关联。结论这篇综述强调了缺乏探索与昼夜节律功能相关的内分泌生物标志物在双相情感障碍睡眠障碍病理生理学中的作用的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Psychiatry PSYCHIATRY-

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

43 days

期刊介绍： The European journal of psychiatry is a quarterly publication founded in 1986 and directed by Professor Seva until his death in 2004. It was originally intended to report “the scientific activity of European psychiatrists” and “to bring about a greater degree of communication” among them. However, “since scientific knowledge has no geographical or cultural boundaries, is open to contributions from all over the world”. These principles are maintained in the new stage of the journal, now expanded with the help of an American editor.