Olga Savushkina , Irina Boksha , Tatyana Prokhorova , Elena Tereshkina , Tatyana Safarova , Olga Yakovleva , Vladimir Kornilov , Elena Shipilova , Elena Vorobyeva , Gulnur Burbaeva
{"title":"Activity of energy, glutamate, and glutathione metabolism enzymes in blood cells of elderly patients with depression","authors":"Olga Savushkina , Irina Boksha , Tatyana Prokhorova , Elena Tereshkina , Tatyana Safarova , Olga Yakovleva , Vladimir Kornilov , Elena Shipilova , Elena Vorobyeva , Gulnur Burbaeva","doi":"10.1016/j.ejpsy.2022.05.001","DOIUrl":null,"url":null,"abstract":"<div><p><span><span>Heterogeneity of depression in older adults is a challenge for the development of person-centered treatment<span>. To address this, we studied glutamate and </span></span>glutathione metabolism enzymes in blood cells in 53 older adult patients with depression and 20 controls. Patients with depression had decreased platelet glutathione-S-transferase and erythrocyte </span>glutathione reductase<span>. The biochemical and clinical data contributed to three clinical clusters that are not linked to the onset of depression or its duration but were related to anxiety, cerebrovascular and cardiovascular comorbidities, including parkinsonian features such as tremor, akathisia, and rigidity. These findings could aid person-centered diagnosis and outcomes and timely successful treatment(s) of depression in older adults.</span></p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Psychiatry","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0213616322000386","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PSYCHIATRY","Score":null,"Total":0}
引用次数: 2
Abstract
Heterogeneity of depression in older adults is a challenge for the development of person-centered treatment. To address this, we studied glutamate and glutathione metabolism enzymes in blood cells in 53 older adult patients with depression and 20 controls. Patients with depression had decreased platelet glutathione-S-transferase and erythrocyte glutathione reductase. The biochemical and clinical data contributed to three clinical clusters that are not linked to the onset of depression or its duration but were related to anxiety, cerebrovascular and cardiovascular comorbidities, including parkinsonian features such as tremor, akathisia, and rigidity. These findings could aid person-centered diagnosis and outcomes and timely successful treatment(s) of depression in older adults.
期刊介绍：
The European journal of psychiatry is a quarterly publication founded in 1986 and directed by Professor Seva until his death in 2004. It was originally intended to report “the scientific activity of European psychiatrists” and “to bring about a greater degree of communication” among them. However, “since scientific knowledge has no geographical or cultural boundaries, is open to contributions from all over the world”. These principles are maintained in the new stage of the journal, now expanded with the help of an American editor.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
