Thermoresponsive polymers: From natural proteins to amino acid based polymer synthesis

IF 26 1区化学 Q1 POLYMER SCIENCE

Progress in Polymer Science Pub Date : 2023-10-22 DOI:10.1016/j.progpolymsci.2023.101752

Mostafa Badreldin , Pedro Salas-Ambrosio , Elisabeth Garanger , Sébastien Lecommandoux , Simon Harrisson , Colin Bonduelle

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Abstract

In polymer science, thermoresponsiveness refers to macromolecular systems that display a marked and discontinuous change in their physical properties with temperature. Such smart polymers are the focus of increasing attention as they provide new solutions to many applications (e.g., drug delivery, nanotechnology, tissue engineering and biotechnology). This review focuses on amino acid based polymers, mainly synthetic polypeptides that are obtained by ring-opening polymerization. These include polymers based on natural amino acids, synthetic or modified amino acids and N-alkylated glycine derivatives. Based on what is known about the behavior of natural proteins in response to temperature variations, this review provides a comprehensive overview of the state of the art of thermosensitive polypeptides through a detailed description i) of the structure/thermoresponsiveness relationship, ii) of the mechanisms involved at the molecular level, iii) of their possible applications both in materials science and in biomedical applications.

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热响应性聚合物:从天然蛋白质到基于氨基酸的聚合物合成

在聚合物科学中，热响应性是指大分子系统的物理性质随温度发生显著和不连续的变化。这种智能聚合物越来越受到关注，因为它们为许多应用（如药物递送、纳米技术、组织工程和生物技术）提供了新的解决方案。这篇综述的重点是基于氨基酸的聚合物，主要是通过开环聚合获得的合成多肽。这些包括基于天然氨基酸、合成或修饰的氨基酸和N-烷基甘氨酸衍生物的聚合物。基于已知的天然蛋白质对温度变化的反应行为，本综述通过详细描述i）结构/热反应性关系，ii）分子水平上涉及的机制，iii）它们在材料科学和生物医学应用中的可能应用。

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来源期刊

Progress in Polymer Science 化学-高分子科学

CiteScore

48.70

自引率

1.10%

发文量

审稿时长

38 days

期刊介绍： Progress in Polymer Science is a journal that publishes state-of-the-art overview articles in the field of polymer science and engineering. These articles are written by internationally recognized authorities in the discipline, making it a valuable resource for staying up-to-date with the latest developments in this rapidly growing field. The journal serves as a link between original articles, innovations published in patents, and the most current knowledge of technology. It covers a wide range of topics within the traditional fields of polymer science, including chemistry, physics, and engineering involving polymers. Additionally, it explores interdisciplinary developing fields such as functional and specialty polymers, biomaterials, polymers in drug delivery, polymers in electronic applications, composites, conducting polymers, liquid crystalline materials, and the interphases between polymers and ceramics. The journal also highlights new fabrication techniques that are making significant contributions to the field. The subject areas covered by Progress in Polymer Science include biomaterials, materials chemistry, organic chemistry, polymers and plastics, surfaces, coatings and films, and nanotechnology. The journal is indexed and abstracted in various databases, including Materials Science Citation Index, Chemical Abstracts, Engineering Index, Current Contents, FIZ Karlsruhe, Scopus, and INSPEC.