Investigation the longevity of hepatitis B surface antibody in vaccinated students of Hormozgan university of medical sciences.

IF 1.3 Q4 MICROBIOLOGY

Iranian Journal of Microbiology Pub Date : 2023-10-01 DOI:10.18502/ijm.v15i5.13876

Majid Najafi-Asl, Soghra Abdi, Mehdi Hassani Azad, Marzieh Norouzian

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Abstract

Background and objectives: Hepatitis B is a common chronic viral infection in humans. Universal use of hepatitis B vaccine is crucial for controlling the infection, but the duration of vaccine-induced immunity remains uncertain. This study aimed to assess hepatitis B antibody levels (anti-HBs) after vaccination in infancy and adolescence, and explore the relationship between immunity levels and variables such as age, sex, BMI, place of birth, and duration since last vaccination among students at Hormozgan University of Medical Sciences from 2019 to 2021.

Materials and methods: The study included 1134 students who completed a questionnaire and provided blood samples for ELISA-based measurement of antibody titers.

Results: The findings revealed that 727 students (64.1%) had no protective antibody level (anti-HBs <10 mIU/ml), 299 (26.4%) had partial immunity (anti-HBs 10-100 mIU/ml), and 108 (9.5%) had complete immunity (anti-HBs >100 mIU/ml). No statistically significant relationships were observed between anti-HBs titer and age, sex, or BMI. However, antibody titer decreased with increasing time since last vaccination (P<0.001).

Conclusion: This study highlights the decline in antibody titer over time following primary vaccination. Sustained immunity against hepatitis B virus relies on antibody durability or robust immunological memory, suggesting the importance of timing booster vaccinations.

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霍尔木兹甘医科大学接种疫苗的学生乙型肝炎表面抗体的寿命调查。

背景与目的：乙型肝炎是人类常见的慢性病毒感染。乙型肝炎疫苗的普遍使用对控制感染至关重要，但疫苗诱导免疫的持续时间仍不确定。本研究旨在评估婴儿期和青少年接种疫苗后的乙型肝炎抗体水平，并探讨免疫水平与年龄、性别、BMI、出生地、，以及自2019年至2021年霍尔莫兹甘医学科学大学学生最后一次接种疫苗以来的持续时间。材料和方法：该研究包括1134名学生，他们完成了问卷调查，并提供了血样用于基于ELISA的抗体滴度测量。结果：727名学生（64.1%）无保护性抗体（抗-HBs 100 mIU/ml）。抗-HBs滴度与年龄、性别或BMI之间没有统计学上的显著关系。然而，自上次接种疫苗以来，抗体滴度随着时间的推移而下降（P结论：本研究强调了初次接种疫苗后抗体滴度随时间的下降。对乙型肝炎病毒的持续免疫依赖于抗体的持久性或强大的免疫记忆，这表明了定时接种加强针的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Iranian Journal of Microbiology MICROBIOLOGY-

CiteScore

2.40

自引率

7.10%

发文量

审稿时长

12 weeks

期刊介绍： The Iranian Journal of Microbiology (IJM) is an international, multi-disciplinary, peer-reviewed journal that provides rapid publication of the most advanced scientific research in the areas of basic and applied research on bacteria and other micro-organisms, including bacteria, viruses, yeasts, fungi, microalgae, and protozoa concerning the development of tools for diagnosis and disease control, epidemiology, antimicrobial agents, clinical microbiology, immunology, Genetics, Genomics and Molecular Biology. Contributions may be in the form of original research papers, review articles, short communications, case reports, technical reports, and letters to the Editor. Research findings must be novel and the original data must be available for review by the Editors, if necessary. Studies that are preliminary, of weak originality or merely descriptive as well as negative results are not appropriate for the journal. Papers considered for publication must be unpublished work (except in an abstract form) that is not under consideration for publication anywhere else, and all co-authors should have agreed to the submission. Manuscripts should be written in English.