Lactoferrin and Activated Protein C: Potential Role in Prevention of Cancer Progression and Recurrence.

IF 1.5 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

International Journal of Molecular and Cellular Medicine Pub Date : 2023-01-01 DOI:10.22088/IJMCM.BUMS.12.1.86

Nahid Akhtar, Atif Khurshid Wani, Musamey Jan, Shruti Sinha, Hari Prasad Devkota, Zijian Li, Mohammad Amin-Ul Mannan, Ajit Prakash

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Abstract

Existing therapeutic interventions for controlling cancer are limited and associated with side effects. Furthermore, the recurrence of cancer poses a significant challenge to the cure of cancer. Therefore, avenues are wanted to find novel therapies for cancer treatment and cancer recurrence. In this review, we have highlighted that lactoferrin (LF) and activated protein C (APC) carry enormous potential in cancer treatment. Studies have shown that the decreased level of APC and impaired function of APC are associated with cancer progression and cancer-related mortality. Moreover, APC plays an important role in preventing prothrombotic state-mediated cancer progression and deaths. LF can also inhibit the progression of cancer by controlling the generation of reactive oxygen species, triggering the apoptosis of cancer cells, arresting the cell cycle and hindering the angiogenesis process. Additionally, APC and LF could have the potential to inhibit neutrophil extracellular traps (NETs) formations which are involved in cancer progression and the reawakening of dormant cancer cells. Hence, in this review, the anticancer potential and mechanism of APC and LF along with their potential to mitigate inflammation and NETs-mediated cancer progression and recurrence has been discussed. Additionally, possible future strategies to develop effective and safe anticancer treatment using LF and APC have also been discussed in this review.

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乳铁蛋白和活化蛋白C：在预防癌症进展和复发中的潜在作用。

现有的控制癌症的治疗干预措施是有限的，并且与副作用相关。此外，癌症的复发对癌症的治疗提出了重大挑战。因此，人们希望找到治疗癌症和癌症复发的新疗法。在这篇综述中，我们强调了乳铁蛋白（LF）和活化蛋白C（APC）在癌症治疗中具有巨大的潜力。研究表明，APC水平下降和APC功能受损与癌症进展和癌症相关死亡率有关。此外，APC在预防血栓前国家介导的癌症进展和死亡方面发挥着重要作用。LF还可以通过控制活性氧的产生、触发癌症细胞凋亡、阻止细胞周期和阻碍血管生成过程来抑制癌症的进展。此外，APC和LF可能具有抑制中性粒细胞外陷阱（NET）形成的潜力，这些陷阱参与了癌症的进展和休眠癌症细胞的重新唤醒。因此，在这篇综述中，讨论了APC和LF的抗癌潜力和机制，以及它们减轻炎症和NETs介导的癌症进展和复发的潜力。此外，本综述还讨论了使用LF和APC开发有效和安全的抗癌治疗的未来可能策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Molecular and Cellular Medicine MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

3.60

自引率

0.00%

发文量

期刊介绍： The International Journal of Molecular and Cellular Medicine (IJMCM) is a peer-reviewed, quarterly publication of Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical Sciences, Babol, Iran. The journal covers all cellular & molecular biology and medicine disciplines such as the genetic basis of disease, biomarker discovery in diagnosis and treatment, genomics and proteomics, bioinformatics, computer applications in human biology, stem cells and tissue engineering, medical biotechnology, nanomedicine, cellular processes related to growth, death and survival, clinical biochemistry, molecular & cellular immunology, molecular and cellular aspects of infectious disease and cancer research. IJMCM is a free access journal. All open access articles published in IJMCM are distributed under the terms of the Creative Commons Attribution CC BY. The journal doesn''t have any submission and article processing charges (APCs).