Long-term exposure to PM_2.5 compositions and O₃ and their interactive effects on DNA methylation of peripheral brain-derived neurotrophic factor promoter.

IF 2.2 4区医学 Q3 ENVIRONMENTAL SCIENCES

International Journal of Environmental Health Research Pub Date : 2024-08-01 Epub Date: 2023-11-08 DOI:10.1080/09603123.2023.2280157

Haoyu Huang, Bing Xie, Yuewei Liu, Guang-Hui Dong, Ruqing Liu, Zhaohuan Gui, Lijun Chen, Shanshan Li, Yuming Guo, Lei Yang, Gongbo Chen

{"title":"Long-term exposure to PM2.5 compositions and O3 and their interactive effects on DNA methylation of peripheral brain-derived neurotrophic factor promoter.","authors":"Haoyu Huang, Bing Xie, Yuewei Liu, Guang-Hui Dong, Ruqing Liu, Zhaohuan Gui, Lijun Chen, Shanshan Li, Yuming Guo, Lei Yang, Gongbo Chen","doi":"10.1080/09603123.2023.2280157","DOIUrl":null,"url":null,"abstract":"This study examined the associations of long-term exposure to ambient fine particulate matter (PM2.5) compositions/ozone with methylation of peripheral brain-derived neurotrophic factor (BDNF) promoters. A total of 101 participants were recruited from a cohort in Shijiazhuang, Hebei province, China. They underwent baseline and follow-up surveys in 2011 and 2015. DNA methylation levels were detected by bisulfite-PCR amplification and pyrosequencing. Participants' three-year average levels of PM2.5 compositions and ozone were estimated. Bayesian kernel machine regression (BKMR) models were used to examine the joint effects of pollutants on methylation levels. Exposure to PM2.5 compositions and ozone mixtures at the 75th percentile was associated with increased methylation levels at CpG2 of BDNF promoter (203%, 95% CI: 89, 316) than the lowest level of exposure, and sulfate dominated the effect in the BKMR models.Our findings provide clues to the epigenetic mechanisms for the associations of PM2.5 compositions and ozone with BDNF.","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":null,"pages":null},"PeriodicalIF":2.2000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Environmental Health Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/09603123.2023.2280157","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/11/8 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

This study examined the associations of long-term exposure to ambient fine particulate matter (PM_2.5) compositions/ozone with methylation of peripheral brain-derived neurotrophic factor (BDNF) promoters. A total of 101 participants were recruited from a cohort in Shijiazhuang, Hebei province, China. They underwent baseline and follow-up surveys in 2011 and 2015. DNA methylation levels were detected by bisulfite-PCR amplification and pyrosequencing. Participants' three-year average levels of PM_2.5 compositions and ozone were estimated. Bayesian kernel machine regression (BKMR) models were used to examine the joint effects of pollutants on methylation levels. Exposure to PM_2.5 compositions and ozone mixtures at the 75th percentile was associated with increased methylation levels at CpG2 of BDNF promoter (203%, 95% CI: 89, 316) than the lowest level of exposure, and sulfate dominated the effect in the BKMR models.Our findings provide clues to the epigenetic mechanisms for the associations of PM_2.5 compositions and ozone with BDNF.

查看原文本刊更多论文

长期暴露于PM2.5成分和O3及其对外周脑源性神经营养因子启动子DNA甲基化的相互作用。

这项研究考察了长期暴露于环境细颗粒物的相关性（PM2.5）组合物/具有外周脑源性神经营养因子（BDNF）启动子甲基化的臭氧。共有101名参与者来自中国河北省石家庄市的一个队列。他们在2011年和2015年接受了基线调查和后续调查。DNA甲基化水平通过亚硫酸氢盐PCR扩增和焦磷酸测序检测。参与者对PM2.5成分和臭氧的三年平均水平进行了估算。贝叶斯核机器回归（BKMR）模型用于检验污染物对甲基化水平的联合影响。在第75百分位暴露于PM2.5成分和臭氧混合物与BDNF启动子CpG2的甲基化水平（203%，95%CI:89316）比最低暴露水平增加有关，并且硫酸盐在BKMR模型中占主导地位。我们的发现为PM2.5成分和臭氧与BDNF相关的表观遗传学机制提供了线索。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

International Journal of Environmental Health Research 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.70

自引率

3.10%

发文量

134

审稿时长

>12 weeks

期刊介绍： International Journal of Environmental Health Research ( IJEHR ) is devoted to the rapid publication of research in environmental health, acting as a link between the diverse research communities and practitioners in environmental health. Published articles encompass original research papers, technical notes and review articles. IJEHR publishes articles on all aspects of the interaction between the environment and human health. This interaction can broadly be divided into three areas: the natural environment and health – health implications and monitoring of air, water and soil pollutants and pollution and health improvements and air, water and soil quality standards; the built environment and health – occupational health and safety, exposure limits, monitoring and control of pollutants in the workplace, and standards of health; and communicable diseases – disease spread, control and prevention, food hygiene and control, and health aspects of rodents and insects. IJEHR is published in association with the International Federation of Environmental Health and includes news from the Federation of international meetings, courses and environmental health issues.

文献相关原料

公司名称	产品信息	采购帮参考价格