Food cue reward salience does not explain Hyperphagia in adolescents with Prader-Willi syndrome.

IF 1.6 4区心理学 Q3 PSYCHOLOGY

Developmental Neuropsychology Pub Date : 2023-10-03 Epub Date: 2023-11-14 DOI:10.1080/87565641.2023.2276950

Menton M Deweese, Elizabeth Roof, Alexandra P Key

引用次数: 0

Abstract

Prader-Willi Syndrome (PWS) is characterized by hyperphagia, an extreme and persistent hunger that emerges in early childhood. We used event-related potentials (ERPs) to objectively investigate brain responses to low- and high-calorie foods, animals, and household objects in 20 satiated adolescents with PWS. Late Positive Potential (LPP) responses to food images did not differ from non-food images. Rather, we observed larger ERPs to high-calorie foods relative to animal images (p=.001) in an earlier time window. These responses correlated with greater severity of hyperphagia (p = .01). Thus, hyperphagia associated with PWS may be due to altered satiety regulation rather than increased motivational salience.

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食物线索奖励显著性不能解释患有Prader-Willi综合征的青少年的过度吞噬。

Prader-Willi综合征（PWS）的特征是进食过度，这是一种在儿童早期出现的极端和持续的饥饿。我们使用事件相关电位（ERPs）客观地研究了20名患有PWS的饱腹青少年对低热量和高热量食物、动物和家居用品的大脑反应。对食物图像的晚期正电位（LPP）反应与非食物图像没有差异。相反，我们在更早的时间窗口中观察到，相对于动物图像，高热量食物的ERP更大（p=0.001）。这些反应与更严重的进食过度相关（p = .01）。因此，与PWS相关的高食欲可能是由于饱腹调节的改变，而不是动机显著性的增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Developmental Neuropsychology 医学-心理学

CiteScore

2.80

自引率

6.70%

发文量

审稿时长

>12 weeks

期刊介绍： Devoted to exploring relationships between brain and behavior across the life span, Developmental Neuropsychology publishes scholarly papers on the appearance and development of behavioral functions, such as language, perception, and social, motivational and cognitive processes as they relate to brain functions and structures. Appropriate subjects include studies of changes in cognitive function—brain structure relationships across a time period, early cognitive behaviors in normal and brain-damaged children, plasticity and recovery of function after early brain damage, the development of complex cognitive and motor skills, and specific and nonspecific disturbances, such as learning disabilities, mental retardation, schizophrenia, stuttering, and developmental aphasia. In the gerontologic areas, relevant subjects include neuropsychological analyses of normal age-related changes in brain and behavioral functions, such as sensory, motor, cognitive, and adaptive abilities; studies of age-related diseases of the nervous system; and recovery of function in later life. Empirical studies, research reviews, case reports, critical commentaries, and book reviews are featured in each issue. By publishing both basic and clinical studies of the developing and aging brain, the journal encourages additional scholarly work that advances understanding of the field of lifespan developmental neuropsychology.

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