Is vestibular function related to human hippocampal volume?

IF 2.9 3区医学 Q2 NEUROSCIENCES

Journal of Vestibular Research-Equilibrium & Orientation Pub Date : 2024-01-01 DOI:10.3233/VES-230076

Joyce Bosmans, Hanne Gommeren, Peter Zu Eulenburg, Annick Gilles, Griet Mertens, Angelique Van Ombergen, Patrick Cras, Sebastiaan Engelborghs, Vincent Van Rompaey

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引用次数: 0

Abstract

Background: Recent studies implicate the effect of vestibular loss on cognitive decline, including hippocampal volume loss. As hippocampal atrophy is an important biomarker of Alzheimer's disease, exploring vestibular dysfunction as a risk factor for dementia and its role in hippocampal atrophy is of interest.

Objective: To replicate previous literature on whole-brain and hippocampal volume in semicircular canal dysfunction (bilateral vestibulopathy; BV) and explore the association between otolith function and hippocampal volume.

Methods: Hippocampal and whole-brain MRI volumes were compared in adults aged between 55 and 83 years. Participants with BV (n = 16) were compared to controls individually matched on age, sex, and hearing status (n = 16). Otolith influence on hippocampal volume in preserved semicircular canal function was evaluated (n = 34).

Results: Whole-brain and targeted hippocampal approaches using volumetric and surface-based measures yielded no significant differences when comparing BV to controls. Binary support vector machines were unable to classify inner ear health status above chance level. Otolith parameters were not associated with hippocampal volume in preserved semicircular canal function.

Conclusions: No significant differences in whole-brain or hippocampal volume were found when comparing BV participants with healthy controls. Saccular parameters in subjects with preserved semicircular canal function were not associated with hippocampal volume changes.

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前庭功能与人类海马体积有关吗？

背景：最近的研究表明前庭功能丧失对认知能力下降的影响，包括海马体积的丧失。由于海马萎缩是阿尔茨海默病的重要生物标志物，探索前庭功能障碍作为痴呆的危险因素及其在海马萎缩中的作用是有意义的。目的：复制以往关于半规管功能障碍（双侧前庭病变；BV）全脑和海马体积的文献，探讨耳石功能与海马体积的关系。方法：比较55岁至83岁成年人的海马和全脑MRI体积。BV（n = 16）分别与年龄、性别和听力状况匹配的对照组进行比较（n = 16）。评价耳石对保留半规管功能的海马体积的影响（n = 34）。结果：与对照组相比，使用体积和表面测量的全脑和靶向海马方法没有显著差异。二进制支持向量机无法对机会水平以上的内耳健康状况进行分类。在保留的半规管功能中，耳石参数与海马体积无关。结论：BV参与者与健康对照组相比，全脑或海马体积没有显著差异。半规管功能保留的受试者的囊参数与海马体积变化无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Vestibular Research-Equilibrium & Orientation 医学-耳鼻喉科学

CiteScore

5.00

自引率

4.30%

发文量

审稿时长

>12 weeks

期刊介绍： Journal of Vestibular Research is a peer-reviewed journal that publishes experimental and observational studies, review papers, and theoretical papers based on current knowledge of the vestibular system. Subjects of the studies can include experimental animals, normal humans, and humans with vestibular or other related disorders. Study topics can include the following: Anatomy of the vestibular system, including vestibulo-ocular, vestibulo-spinal, and vestibulo-autonomic pathways Balance disorders Neurochemistry and neuropharmacology of balance, both at the systems and single neuron level Neurophysiology of balance, including the vestibular, ocular motor, autonomic, and postural control systems Psychophysics of spatial orientation Space and motion sickness Vestibular rehabilitation Vestibular-related human performance in various environments

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