Autologous fat injection for empty-nose syndrome

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-08-01 DOI:10.1016/j.anorl.2023.10.017

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引用次数: 0

Abstract

Aims

Inferior meatus augmentation by injection or implants is one of the treatments for empty-nose syndrome (ENS), but levels of evidence of efficacy are low. We present the technique and evaluate our experience. The primary objective was to analyze changes in Empty Nose Syndrome 6-item Questionnaire (ENS6Q) scores after treating patients with ENS by autologous fat injection. Secondary objectives were the analysis of the evolution of each of the six ENS6Q items and identification of complications. Eleven patients underwent a minimally invasive approach to limit nasal airflow using fat injection between March 2021 and December 2022.

Results

Ten of the 11 patients showed a decrease in overall ENS6Q score (P = 0.0058); 6 had a final ENS6Q score < 11. Ten were satisfied with the procedure, but remained symptomatic. The procedure did not result in any complications.

Conclusion

These encouraging results confirm the data in the literature suggesting that fat injection improves symptomatology in empty nose syndrome. However, like other minimally invasive approaches to limit nasal airflow, it does not eliminate all symptoms. These results need to be confirmed by studies on larger cohorts with longer follow-up, preferably in a multicenter setting.

查看原文本刊更多论文

自体脂肪注射治疗空鼻综合征。

目的：注射或植入下鼻道是治疗空鼻综合征（ENS）的方法之一，但疗效证据水平较低。我们展示技术并评估我们的经验。主要目的是分析自体脂肪注射治疗ENS患者后，空鼻综合征6项问卷（ENS6Q）评分的变化。次要目标是分析六个ENS6Q项目中每一个项目的演变情况并确定并发症。在2021年3月至2022年12月期间，11名患者接受了脂肪注射限制鼻腔气流的微创方法。结果：11名患者中有10名患者的总体ENS6Q评分下降（P=0.0058）；结论：这些令人鼓舞的结果证实了文献中的数据，表明脂肪注射可以改善空鼻综合征的症状。然而，与其他限制鼻腔气流的微创方法一样，它并不能消除所有症状。这些结果需要通过对更大队列进行更长随访的研究来证实，最好是在多中心环境中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.