Neonatal Hip Loading in Developmental Dysplasia: Finite Element Simulation of Proximal Femur Growth and Treatment.

IF 1.6 4区医学 Q3 ORTHOPEDICS

Hss Journal Pub Date : 2023-11-01 Epub Date: 2023-09-13 DOI:10.1177/15563316231193426

S Mahsa Sadeghian, Owen J Arthurs, Xinshan Li, Cara L Lewis, Sandra J Shefelbine

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引用次数: 0

Abstract

Background: Abnormal prenatal hip joint loading can lead to compromised hip joint function. Early intervention is crucial for favorable outcomes.

Purpose: This study investigates the impact of treatment timing (initiation and duration) on cartilage growth and ossification in the proximal femur of infants with developmental dysplasia of the hip, a condition affecting newborns.

Methods: We used a mechanobiological model to simulate proximal femur growth during treatment durations of 3 months, 6 months, and a late-start treatment.

Results: The findings indicate that the timing of treatment initiation is crucial, while a longer treatment duration does not contribute to improved morphological development of the hip joint.

Conclusions: Mechanobiological models of growth can be used to develop treatments and therapies that correct loading conditions. Growing bone is particularly sensitive to loading conditions, and altered loading during growth can affect bone shape and functionality.

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发育不良新生儿髋关节负荷：股骨近端生长和治疗的有限元模拟。

背景：产前髋关节负荷异常可导致髋关节功能受损。早期干预对取得良好结果至关重要。目的：本研究探讨治疗时机（开始和持续时间）对患有发育性髋关节发育不良的婴儿股骨近端软骨生长和骨化的影响，这种情况会影响新生儿。方法：我们使用机械生物学模型来模拟3个月、6个月和延迟开始治疗期间股骨近端的生长。结果：研究结果表明，开始治疗的时间至关重要，而较长的治疗时间对改善髋关节的形态发育没有帮助。结论：生长的机械生物学模型可用于开发纠正负荷条件的治疗方法。生长中的骨骼对负载条件特别敏感，生长过程中负载的改变会影响骨骼的形状和功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hss Journal Medicine-Surgery

CiteScore

3.90

自引率

0.00%

发文量

期刊介绍： The HSS Journal is the Musculoskeletal Journal of Hospital for Special Surgery. The aim of the HSS Journal is to promote cutting edge research, clinical pathways, and state-of-the-art techniques that inform and facilitate the continuing education of the orthopaedic and musculoskeletal communities. HSS Journal publishes articles that offer contributions to the advancement of the knowledge of musculoskeletal diseases and encourages submission of manuscripts from all musculoskeletal disciplines.