Impact of palliative-intent radiotherapy with or without chemotherapy on lameness in flat coat retrievers with localised periarticular histiocytic sarcoma - a retrospective cohort, single institution study.

IF 2.3 2区 农林科学 Q1 VETERINARY SCIENCES
Veterinary and comparative oncology Pub Date : 2024-03-01 Epub Date: 2023-11-07 DOI:10.1111/vco.12942
Petros Odatzoglou, Thomas Kearns, Charlie Pittaway, Jane M Dobson
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引用次数: 0

Abstract

Histiocytic sarcoma (HS) is a common tumour in flat coat retrievers (FCRs) often affecting periarticular tissues and joints. Palliative-intent radiotherapy, seeks to achieve local tumour control, pain relief and improve limb function. However, the effect of palliative-intent radiotherapy on analgesic levels of dogs with localised HS has not been studied. We hypothesised that palliative-intent radiotherapy could improve lameness in dogs affected by localised HS. This study aimed to assess the impact of palliative-intent radiotherapy on lameness of FCRs with localised HS. A retrospective cohort single institution study was performed. Medical records of FCR dogs with HS that received external beam radiotherapy between 2003 and 2022 were reviewed and included demographic, staging, severity of baseline lameness, therapeutic management and outcome data. Descriptive statistics, McNemar's chi-squared test, Fisher's exact test and Kaplan-Meier analysis were used for statistical analysis. Thirty-nine dogs were included with a median age of 7.2 years, 25 were male and 14 were female. HS was most commonly located in the forelimb (29 dogs, 74.3%), affecting the shoulder joint (19 dogs, 48.7%). Staging was performed in all 39 dogs with 22 (56.4%) dogs having localised HS, six (15.3%) dogs had localised HS with node metastasis and 11 (28.2%) dogs had localised HS with systemic metastasis. All dogs received palliative-intent hypo-fractionated radiation therapy, 32 (82%) dogs showed improvement in lameness. In conclusion, palliative intent radiation treatment has an analgesic effect reducing lameness or clinical signs associated with affected tumour-bearing joints.

姑息性放疗加或不加化疗对局部关节周围组织细胞肉瘤扁平毛寻回犬跛行的影响——一项回顾性队列、单一机构研究。
组织细胞肉瘤(HS)是扁平毛寻回犬(FCRs)中常见的肿瘤,通常影响关节周围组织和关节。意向性姑息性放射治疗,旨在实现局部肿瘤控制、疼痛缓解和改善肢体功能。然而,姑息性放疗对局部HS犬镇痛水平的影响尚未得到研究。我们假设,姑息性放疗可以改善局部HS影响的狗的跛行。本研究旨在评估姑息性放疗对伴有局部HS的FCRs跛行的影响。进行了一项回顾性队列单机构研究。回顾了2003年至2022年间接受外束放射治疗的患有HS的FCR犬的医疗记录,包括人口统计学、分期、基线跛行的严重程度、治疗管理和结果数据。统计分析采用描述性统计学、McNemar卡方检验、Fisher精确检验和Kaplan-Meier分析。39只狗被纳入研究,中位年龄为7.2岁 男25例,女14例。HS最常见于前肢(29只,74.3%),影响肩关节(19只,48.7%)。对所有39只狗进行了分期,其中22只(56.4%)狗患有局部HS,6只(15.3%)狗患有伴有淋巴结转移的局部HS,11只(28.2%)狗患有伴有全身转移的局部性HS。所有狗都接受了姑息性低分级放射治疗,32只(82%)狗的跛行情况有所改善。总之,姑息性放射治疗具有镇痛作用,可以减少跛足或与受影响的肿瘤关节相关的临床症状。
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来源期刊
Veterinary and comparative oncology
Veterinary and comparative oncology 农林科学-兽医学
CiteScore
4.80
自引率
9.50%
发文量
75
审稿时长
>24 weeks
期刊介绍: Veterinary and Comparative Oncology (VCO) is an international, peer-reviewed journal integrating clinical and scientific information from a variety of related disciplines and from worldwide sources for all veterinary oncologists and cancer researchers concerned with aetiology, diagnosis and clinical course of cancer in domestic animals and its prevention. With the ultimate aim of diminishing suffering from cancer, the journal supports the transfer of knowledge in all aspects of veterinary oncology, from the application of new laboratory technology to cancer prevention, early detection, diagnosis and therapy. In addition to original articles, the journal publishes solicited editorials, review articles, commentary, correspondence and abstracts from the published literature. Accordingly, studies describing laboratory work performed exclusively in purpose-bred domestic animals (e.g. dogs, cats, horses) will not be considered.
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