Multisystem Inflammatory Syndrome (MIS) following SARS-CoV-2 vaccinations; a systematic review.

IF 2.4 Q3 INFECTIOUS DISEASES
Mohamed Elsaid, Arvind Nune, Deyaa Hesham, Fatma Mohamed Fouad, Hamsa Hassan, Heba Hamouda, Huda Sherif, Maya Magdy Abdelwahab, Nourelhoda Hegazi, Yasmena Abd El-Rahman
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Abstract

Background: Although SARS-CoV-2 vaccines are generally safe, there are growing concerns about their link to a potentially life-threatening multi-system inflammatory syndrome following vaccination (MIS-V). We conducted this systematic review to elucidate the prevalence of MIS, severity, treatment, and outcomes following SARS-CoV-2 vaccination.

Methods: We searched PubMed, Scopus, ScienceDirect, Google Scholar, Virtual Health Library (VHL), Cochrane Library, and Web of Science databases for articles and case reports about MIS-V. We performed a qualitative analysis of individual cases from the included studies.

Results: Of the 1366 studies identified by database search, we retrieved twenty-six case reports and two cohort studies. We analyzed the data of 37 individual cases extracted from 27 articles. The average age of the cases included in this review was 18 (1-67) years, with the most being male (M: F 3.1:1). Of the 37 included cases, the cardiovascular system was the most affected system by MIS (36, 97.3%), followed by the gastrointestinal tract (32, 86.5%).

Conclusion: MIS after SARS-CoV-2 vaccinations can be fatal, but the incidence is low. Prompt recognition of MIS and ruling out the mimickers are critical in the patient's early recovery.

Abstract Image

接种严重急性呼吸系统综合征冠状病毒2型疫苗后的多系统炎症综合征;系统的回顾。
背景:尽管严重急性呼吸系统综合征冠状病毒2型疫苗总体上是安全的,但人们越来越担心它们与接种疫苗后可能危及生命的多系统炎症综合征(MIS-V)的联系。我们进行了这项系统综述,以阐明接种严重急性呼吸系统综合征冠状病毒2型疫苗后MIS的患病率、严重程度、治疗和结果。方法:我们在PubMed、Scopus、ScienceDirect、Google Scholar、虚拟健康图书馆(VHL)、Cochrane图书馆和Web of Science数据库中搜索有关MIS-V的文章和病例报告。我们对纳入研究的个别病例进行了定性分析。结果:在通过数据库搜索确定的1366项研究中,我们检索了26份病例报告和两项队列研究。我们分析了从27篇文章中提取的37个个案的数据。纳入本综述的病例的平均年龄为18(1-67)岁,其中男性最多(M:F3.1:1)。在37例纳入病例中,心血管系统受MIS影响最大(3697.3%),其次是胃肠道(3286.5%)。结论:接种严重急性呼吸系统综合征冠状病毒2型疫苗后的MIS可能致命,但发病率较低。及时识别MIS并排除模仿者对患者的早期康复至关重要。
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来源期刊
CiteScore
5.20
自引率
0.00%
发文量
25
审稿时长
17 weeks
期刊介绍: Tropical Diseases, Travel Medicine and Vaccines is an open access journal that considers basic, translational and applied research, as well as reviews and commentary, related to the prevention and management of healthcare and diseases in international travelers. Given the changes in demographic trends of travelers globally, as well as the epidemiological transitions which many countries are experiencing, the journal considers non-infectious problems including chronic disease among target populations of interest as well as infectious diseases.
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