Advances in PET Imaging of the CXCR4 Receptor: [68Ga]Ga-PentixaFor

IF 4.6 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Liza Lindenberg MD , Mark Ahlman MD , Frank Lin MD , Esther Mena MD , Peter Choyke MD
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引用次数: 0

Abstract

[68Ga]Ga-PentixaFor, a PET agent targeting CXCR4 is emerging as a versatile radiotracer with promising applications in oncology, cardiology and inflammatory disease. Preclinical work in various cancer cell lines have demonstrated high specificity and selectivity. In human investigations of several tumors, the most promising applications may be in multiple myeloma, certain lymphomas and myeloproliferative neoplasms. In the nononcologic setting, [68Ga]Ga-PentixaFor could greatly improve detection for primary aldosteronism and other endocrine abnormalities. Similarly, atherosclerotic disease and other inflammatory conditions could also benefit from enhanced identification by CXCR4 targeting. Rapidly cleared from the body with a favorable imaging and radiation dosimetry profile that has been already studied in over 1000 patients, [68Ga]Ga-PentixaFor is a worthy agent for further clinical exploration with potential for theranostic applications in hematologic malignancies.

CXCR4受体的PET成像研究进展:[68Ga]Ga PentixaFor。
[68Ga]Ga PentixaFor,一种靶向CXCR4的PET试剂正在成为一种多功能放射性示踪剂,在肿瘤学、心脏病学和炎症疾病中有着很好的应用前景。在各种癌症细胞系中的临床前工作已经证明了高特异性和选择性。在人类对几种肿瘤的研究中,最有前景的应用可能是多发性骨髓瘤、某些淋巴瘤和骨髓增生性肿瘤。在非肿瘤环境中,[68Ga]Ga PentixaFor可以极大地改善原发性醛固酮增多症和其他内分泌异常的检测。同样,动脉粥样硬化性疾病和其他炎症性疾病也可以受益于CXCR4靶向增强的鉴定。[68Ga]Ga PentixaFor具有良好的成像和辐射剂量测定特性,已在1000多名患者中进行了研究,可迅速从体内清除,是一种值得进一步临床探索的药物,在血液系统恶性肿瘤的治疗应用中具有潜力。
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来源期刊
Seminars in nuclear medicine
Seminars in nuclear medicine 医学-核医学
CiteScore
9.80
自引率
6.10%
发文量
86
审稿时长
14 days
期刊介绍: Seminars in Nuclear Medicine is the leading review journal in nuclear medicine. Each issue brings you expert reviews and commentary on a single topic as selected by the Editors. The journal contains extensive coverage of the field of nuclear medicine, including PET, SPECT, and other molecular imaging studies, and related imaging studies. Full-color illustrations are used throughout to highlight important findings. Seminars is included in PubMed/Medline, Thomson/ISI, and other major scientific indexes.
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