Hypoxia signaling and metastatic progression

IF 12.1 1区医学 Q1 ONCOLOGY

Seminars in cancer biology Pub Date : 2023-11-04 DOI:10.1016/j.semcancer.2023.11.001

Luana Schito , Sergio Rey-Keim

引用次数: 0

Abstract

Disruption of oxygen homeostasis, resulting from an imbalance between O₂ supply and demand during malignant proliferation, leads to the development of hypoxic tumor microenvironments that promote the acquisition of aggressive cancer cell phenotypes linked to metastasis and patient mortality. In this review, the mechanistic links between tumor hypoxia and metastatic progression are presented. Current status and perspectives of targeting hypoxia signaling pathways as a strategy to halt cancer cell metastatic activities are emphasized.

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缺氧信号传导与转移进展。

恶性增殖过程中氧气供需失衡导致氧气稳态的破坏，导致缺氧肿瘤微环境的发展，从而促进与转移和患者死亡率相关的侵袭性癌症细胞表型的获得。在这篇综述中，肿瘤缺氧和转移进展之间的机制联系提出。强调了靶向缺氧信号通路作为阻止癌症细胞转移活性的策略的现状和前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in cancer biology 医学-肿瘤学

CiteScore

26.80

自引率

4.10%

发文量

347

审稿时长

15.1 weeks

期刊介绍： Seminars in Cancer Biology (YSCBI) is a specialized review journal that focuses on the field of molecular oncology. Its primary objective is to keep scientists up-to-date with the latest developments in this field. The journal adopts a thematic approach, dedicating each issue to an important topic of interest to cancer biologists. These topics cover a range of research areas, including the underlying genetic and molecular causes of cellular transformation and cancer, as well as the molecular basis of potential therapies. To ensure the highest quality and expertise, every issue is supervised by a guest editor or editors who are internationally recognized experts in the respective field. Each issue features approximately eight to twelve authoritative invited reviews that cover various aspects of the chosen subject area. The ultimate goal of each issue of YSCBI is to offer a cohesive, easily comprehensible, and engaging overview of the selected topic. The journal strives to provide scientists with a coordinated and lively examination of the latest developments in the field of molecular oncology.