Comparative Study of Liposomal and Ethosomal Formulations of Curcuma heyneana Rhizome Extract in a Transdermal Delivery System.

Q2 Pharmacology, Toxicology and Pharmaceutics

Pharmaceutical nanotechnology Pub Date : 2025-01-01 DOI:10.2174/0122117385252518231018161755

Idha Kusumawati, Kresma Oky Kurniawan, Rohmania Rohmania, Bernasdito Ade Pratama, Yusuf Alif Pratama, Subhan Rullyansyah, Mega Ferdina Warsito, Retno Widyowati, Eka Pramyrtha Hestianah, Katsuyoshi Matsunami

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引用次数: 0

Abstract

Aims: This study aimed to develop an anti-aging nanoformulation with Curcuma heyneana extract as bioactive substance.

Background: Curcuma heyneana Valeton & Zipj extract has been proven in previous research to have antioxidant, anti-ageing, anti-inflammatory, and wound healing properties, which makes it a potential bioactive material for anti-ageing and sunscreen cosmetic products. Phytoantioxidants need to penetrate into deeper skin layers to ensure effectivity. Thus, a transdermal delivery system is needed to deliver the extract to a deeper skin layer.

Objectives: The objective of the study was to compare the permeability and anti-ageing activity of liposomal and ethosomal formulations of C. heynena rhizome ethanolic extract.

Methods: In this study, C. heyneana extract was loaded into a phospholipid vesicular system in the form of liposome and ethosome formulations using the ethanolic injection method. The anti-ageing activity was assessed by analyzing the epidermal thickness, number of sunburn cells, distance between collagen fibers, and number of fibroblasts. While the histologic specimen scoring was carried out for the in vivo penetration study.

Results: The ethosomal formulation had been found to have better penetration ability since it was able to reach the lower dermis area compared to the liposomes, which only reached the upper dermis. The ethosomal formulation of C. heyneana extract exhibited a better anti-ageing activity based on the parameters of epidermal thickness, sunburn cell count, fibroblast count, and the distance between collagen fibres in rat skin histology.

Conclusion: Ethosomes have been found to be a more proficient carrier system for transdermal delivery of C. heyneana extract compared to liposomes. Meanwhile, their penetration correlated with the effectivity of the formulation, suggesting that the vesicular system enhanced the penetration ability of the extract.

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姜黄根状茎提取物在透皮给药系统中的脂质体和质体配方的比较研究。

目的：本研究旨在开发一种以莪术提取物为生物活性物质的抗衰老纳米制剂。背景：姜黄提取物在先前的研究中已被证明具有抗氧化、抗衰老、抗炎和伤口愈合的特性，这使其成为抗衰老和防晒化妆品的潜在生物活性材料。植物抗氧化剂需要渗透到更深的皮肤层，以确保有效性。因此，需要经皮递送系统来将提取物递送到更深的皮肤层。目的：比较何首乌乙醇提取物脂质体和醇质体制剂的渗透性和抗衰老活性。方法：采用乙醇注射法，以脂质体和醇质体的形式将何首乌提取物加载到磷脂囊泡系统中。通过分析表皮厚度、晒伤细胞数量、胶原纤维之间的距离和成纤维细胞数量来评估抗衰老活性。而组织学标本评分则用于体内渗透研究。结果：与仅到达真皮上部的脂质体相比，醇质体制剂具有更好的穿透能力，因为它能够到达真皮下部区域。根据大鼠皮肤组织学中的表皮厚度、晒伤细胞计数、成纤维细胞计数和胶原纤维之间的距离等参数，heyneana提取物的醇体制剂表现出更好的抗衰老活性。结论：与脂质体相比，Ethosomes是一种更适合于heyneana提取物透皮给药的载体系统。同时，它们的渗透性与制剂的有效性相关，表明水疱系统增强了提取物的渗透能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmaceutical nanotechnology Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

4.20

自引率

0.00%

发文量

期刊介绍： Pharmaceutical Nanotechnology publishes original manuscripts, full-length/mini reviews, thematic issues, rapid technical notes and commentaries that provide insights into the synthesis, characterisation and pharmaceutical (or diagnostic) application of materials at the nanoscale. The nanoscale is defined as a size range of below 1 µm. Scientific findings related to micro and macro systems with functionality residing within features defined at the nanoscale are also within the scope of the journal. Manuscripts detailing the synthesis, exhaustive characterisation, biological evaluation, clinical testing and/ or toxicological assessment of nanomaterials are of particular interest to the journal’s readership. Articles should be self contained, centred around a well founded hypothesis and should aim to showcase the pharmaceutical/ diagnostic implications of the nanotechnology approach. Manuscripts should aim, wherever possible, to demonstrate the in vivo impact of any nanotechnological intervention. As reducing a material to the nanoscale is capable of fundamentally altering the material’s properties, the journal’s readership is particularly interested in new characterisation techniques and the advanced properties that originate from this size reduction. Both bottom up and top down approaches to the realisation of nanomaterials lie within the scope of the journal.