Arginase inhibitory activities of chemical constituents from Macaranga hurifolia Beille leaves.

IF 1.9 3区 化学 Q3 CHEMISTRY, APPLIED
Natural Product Research Pub Date : 2024-12-01 Epub Date: 2023-11-05 DOI:10.1080/14786419.2023.2275267
Andy Zedet, Yao Kanga, Marc Pudlo, François Senejoux, Corine Girard
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引用次数: 0

Abstract

The methanolic extract of the leaves of Macaranga hurifolia Beille showed arginase inhibitory activity (40% at 100 µg/mL) and was then fractionated to obtain nine polyphenolic compounds. Their structures were elucidated on the basis of NMR spectroscopic data, and by comparison with data previously reported in the literature, as gallic acid (1), 3,4-dihydroxybenzoic acid (2), chlorogenic acid, (3), corilagin (4), cynaroside (5), cosmosiin (6), hyperoside (7) isoquercitrin (8) and guajaverin (9). These compounds have been evaluated as arginase inhibitors. Compounds 4, 7, 8 and 9 showed varying arginase inhibitory activities with IC50 values ranging from 102 to 302 μM. All the isolated compounds were previously identified in this species but their activities on arginase are reported here for the first time.

山核桃叶化学成分对精氨酸酶的抑制活性。
胡杨叶的甲醇提取物显示出精氨酸酶抑制活性(在100 µg/mL),然后分馏以获得九种多酚化合物。它们的结构是在NMR光谱数据的基础上,并通过与文献中先前报道的数据进行比较来阐明的,如没食子酸(1)、3,4-二羟基苯甲酸(2)、绿原酸(3)、珊瑚苷(4)、cynarosin(5)、cosmosiin(6)、金丝桃苷(7)、异槲皮苷(8)和瓜哈韦林(9)。这些化合物已被评价为精氨酸酶抑制剂。化合物4、7、8和9显示出不同的精氨酸酶抑制活性,IC50值在102至302之间 μM。所有分离的化合物以前都在该物种中鉴定过,但它们对精氨酸酶的活性在这里是首次报道。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Natural Product Research
Natural Product Research 化学-医药化学
CiteScore
5.10
自引率
9.10%
发文量
605
审稿时长
2.1 months
期刊介绍: The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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