Applicability of multiple quantitative magnetic resonance methods in genetic brain white matter disorders

IF 2.3 4区医学 Q3 CLINICAL NEUROLOGY

Journal of Neuroimaging Pub Date : 2023-11-04 DOI:10.1111/jon.13167

Menno D. Stellingwerff, Murtadha L. Al-Saady, Kwok-Shing Chan, Adam Dvorak, José P. Marques, Shannon Kolind, Stefan D. Roosendaal, Nicole I. Wolf, Frederik Barkhof, Marjo S. van der Knaap, Petra J. W. Pouwels

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引用次数: 0

Abstract

Background and purpose

Magnetic resonance imaging (MRI) measures of tissue microstructure are important for monitoring brain white matter (WM) disorders like leukodystrophies and multiple sclerosis. They should be sensitive to underlying pathological changes. Three whole-brain isotropic quantitative methods were applied and compared within a cohort of controls and leukodystrophy patients: two novel myelin water imaging (MWI) techniques (multi-compartment relaxometry diffusion-informed MWI: MCR-DIMWI, and multi-echo T2 relaxation imaging with compressed sensing: METRICS) and neurite orientation dispersion and density imaging (NODDI).

Methods

For 9 patients with different leukodystrophies (age range 0.4-62.4 years) and 15 control subjects (2.3-61.3 years), T1-weighted MRI, fluid-attenuated inversion recovery, multi-echo gradient echo with variable flip angles, METRICS, and multi-shell diffusion-weighted imaging were acquired on 3 Tesla. MCR-DIMWI, METRICS, NODDI, and quality control measures were extracted to evaluate differences between patients and controls in WM and deep gray matter (GM) regions of interest (ROIs). Pearson correlations, effect size calculations, and multi-level analyses were performed.

Results

MCR-DIMWI and METRICS-derived myelin water fractions (MWFs) were lower and relaxation times were higher in patients than in controls. Effect sizes of MWF values and relaxation times were large for both techniques. Differences between patients and controls were more pronounced in WM ROIs than in deep GM. MCR-DIMWI-MWFs were more homogeneous within ROIs and more bilaterally symmetrical than METRICS-MWFs. The neurite density index was more sensitive in detecting differences between patients and controls than fractional anisotropy. Most measures obtained from MCR-DIMWI, METRICS, NODDI, and diffusion tensor imaging correlated strongly with each other.

Conclusion

This proof-of-concept study shows that MCR-DIMWI, METRICS, and NODDI are sensitive techniques to detect changes in tissue microstructure in WM disorders.

Abstract Image

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多种定量磁共振方法在遗传性脑白质疾病中的适用性。

背景和目的：组织微观结构的磁共振成像（MRI）测量对于监测脑白质（WM）疾病如白细胞营养不良和多发性硬化症非常重要。他们应该对潜在的病理变化敏感。在对照组和脑白质营养不良患者中应用并比较了三种全脑各向同性定量方法：两种新的髓鞘水成像（MWI）技术（多室弛豫扩散告知MWI:MCR-DIMWI和压缩传感的多回声T2弛豫成像：METRICS）和神经突定向分散和密度成像（NODDI）不同白细胞营养不良患者（年龄范围0.4-62.4岁）和15名对照受试者（2.3-61.3岁），在3特斯拉上获得T1加权MRI、液体衰减反转恢复、可变翻转角多回波梯度回波、METRICS和多壳扩散加权成像。提取MCR-DIMWI、METRICS、NODDI和质量控制指标，以评估患者和对照组在WM和深灰质（GM）感兴趣区域（ROI）方面的差异。进行了皮尔逊相关、效应大小计算和多层次分析。结果：与对照组相比，患者的MCR-DIMWI和METRICS衍生的髓鞘水分数（MWF）较低，松弛时间较高。MWF值和弛豫时间的效应大小对于这两种技术都很大。患者和对照组之间的差异在WM ROI中比在深GM中更明显。MCR DIMWI MWF在ROI内更均匀，比METRICS MWF更双侧对称。轴突密度指数在检测患者和对照组之间的差异方面比分数各向异性更敏感。从MCR-DIMWI、METRICS、NODDI和扩散张量成像获得的大多数测量结果彼此之间具有很强的相关性。结论：这项概念验证研究表明，MCR-DIMWI、METRICS和NODDI是检测WM疾病组织微观结构变化的敏感技术。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Neuroimaging 医学-核医学

CiteScore

4.70

自引率

0.00%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Start reading the Journal of Neuroimaging to learn the latest neurological imaging techniques. The peer-reviewed research is written in a practical clinical context, giving you the information you need on: MRI CT Carotid Ultrasound and TCD SPECT PET Endovascular Surgical Neuroradiology Functional MRI Xenon CT and other new and upcoming neuroscientific modalities.The Journal of Neuroimaging addresses the full spectrum of human nervous system disease, including stroke, neoplasia, degenerating and demyelinating disease, epilepsy, tumors, lesions, infectious disease, cerebral vascular arterial diseases, toxic-metabolic disease, psychoses, dementias, heredo-familial disease, and trauma.Offering original research, review articles, case reports, neuroimaging CPCs, and evaluations of instruments and technology relevant to the nervous system, the Journal of Neuroimaging focuses on useful clinical developments and applications, tested techniques and interpretations, patient care, diagnostics, and therapeutics. Start reading today!