Recent advances in caspase-3, breast cancer, and traditional Chinese medicine: a review.

IF 1.9 4区医学 Q3 INFECTIOUS DISEASES

Journal of Chemotherapy Pub Date : 2024-09-01 Epub Date: 2023-11-07 DOI:10.1080/1120009X.2023.2278014

He Dou, Ping Yang Yu, Yu Qi Liu, Yue Zhu, Fu Cheng Li, You Yu Wang, Xing Yan Chen, Min Xiao

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引用次数: 0

Abstract

Caspases (cysteinyl aspartate-specific proteinases) are a group of structurally similar proteases in the cytoplasm that can be involved in cell differentiation, programmed death, proliferation, and inflammatory generation. Experts have found that caspase-3 can serve as a terminal splicing enzyme in apoptosis and participate in the mechanism by which cytotoxic drugs kill cancer cells. Breast cancer (BC) has become the most common cancer among women worldwide, posing a severe threat to their lives. Finding new therapeutic targets for BC is the primary task of contemporary physicians. Numerous studies have revealed the close association between caspase-3 expression and BC. Caspase-3 is essential in BC's occurrence, invasion, and metastasis. In addition, Caspase-3 exerts anticancer effects by regulating cell death mechanisms. Traditional Chinese medicine acting through caspase-3 expression is increasingly used in clinical treatment. This review summarizes the biological mechanism of caspase-3 and research progress on BC. It introduces a variety of traditional Chinese medicine related to caspase-3 to provide new ideas for the clinical treatment of BC.

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半胱氨酸天冬氨酸蛋白酶-3、乳腺癌症和中药的最新进展：综述。

半胱天冬氨酸蛋白酶（半胱氨酸天冬氨酸特异性蛋白酶）是细胞质中一组结构相似的蛋白酶，可参与细胞分化、程序性死亡、增殖和炎症生成。专家发现，胱天蛋白酶-3可以作为细胞凋亡的末端剪接酶，参与细胞毒性药物杀死癌症细胞的机制。癌症（BC）已成为全球女性中最常见的癌症，对她们的生命构成严重威胁。为BC寻找新的治疗靶点是当代医生的首要任务。大量研究揭示了胱天蛋白酶-3的表达与BC之间的密切联系。Caspase-3在BC的发生、侵袭和转移中起重要作用。此外，Caspase-3通过调节细胞死亡机制发挥抗癌作用。中药通过胱天蛋白酶-3的表达发挥作用，在临床治疗中得到越来越多的应用。本文综述了胱天蛋白酶-3的生物学机制及对BC的研究进展。介绍了多种与胱天蛋白酶-3相关的中药，为BC的临床治疗提供新思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Chemotherapy 医学-药学

CiteScore

3.70

自引率

0.00%

发文量

144

审稿时长

6-12 weeks

期刊介绍： The Journal of Chemotherapy is an international multidisciplinary journal committed to the rapid publication of high quality, peer-reviewed, original research on all aspects of antimicrobial and antitumor chemotherapy. The Journal publishes original experimental and clinical research articles, state-of-the-art reviews, brief communications and letters on all aspects of chemotherapy, providing coverage of the pathogenesis, diagnosis, treatment, and control of infection, as well as the use of anticancer and immunomodulating drugs. Specific areas of focus include, but are not limited to: · Antibacterial, antiviral, antifungal, antiparasitic, and antiprotozoal agents; · Anticancer classical and targeted chemotherapeutic agents, biological agents, hormonal drugs, immunomodulatory drugs, cell therapy and gene therapy; · Pharmacokinetic and pharmacodynamic properties of antimicrobial and anticancer agents; · The efficacy, safety and toxicology profiles of antimicrobial and anticancer drugs; · Drug interactions in single or combined applications; · Drug resistance to antimicrobial and anticancer drugs; · Research and development of novel antimicrobial and anticancer drugs, including preclinical, translational and clinical research; · Biomarkers of sensitivity and/or resistance for antimicrobial and anticancer drugs; · Pharmacogenetics and pharmacogenomics; · Precision medicine in infectious disease therapy and in cancer therapy; · Pharmacoeconomics of antimicrobial and anticancer therapies and the implications to patients, health services, and the pharmaceutical industry.