Effect of royal jelly on acrylamide-induced neurotoxicity in rats

IF 2.7 4区医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of chemical neuroanatomy Pub Date : 2023-11-02 DOI:10.1016/j.jchemneu.2023.102358

Doaa S. Ibrahim , Eman M.S. Shahen

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引用次数: 0

Abstract

Royal Jelly (RJ) is a natural product made by nurse bees known for its multiple therapeutic properties. The research aims to discover the ability of RJ to improve the hematological alterations and neurotoxicity caused by acrylamide (AA). The study rats were separated equally into four groups (6 in each group), the control group, the AA (38.27 mg/kg bw) group, the RJ (150 mg/kg bw) + AA group, and the RJ (300 mg/kg bw) + AA group. Blood and brain samples were collected after 10 days to evaluate haematological and biochemical parameters and to examine histopathological and immunohistochemistry. The administration of AA increased the level of malondialdehyde (MDA), decreases levels of haematological parameters, superoxide dismutase (SOD), reduced glutathione (GSH), brain-derived neurotrophic factor (BDNF), neurotransmitters (serotonin, dopamine, and acetylcholine), and cleaved caspase-3, as well as increase the damage to the brain tissues. Meanwhile, RJ improved levels of haematological parameters, oxidative stress parameters (MDA, SOD, and GSH), BDNF, neurotransmitters, cleaved caspase-3, and brain tissue damage induced by AA. The study demonstrated the protective impact of RJ against the haematological alterations and neurotoxicity caused by AA.

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蜂王浆对丙烯酰胺致大鼠神经毒性的影响。

蜂王浆（RJ）是一种由护理蜂制成的天然产品，以其多种治疗特性而闻名。本研究旨在发现RJ改善丙烯酰胺（AA）引起的血液学改变和神经毒性的能力。研究大鼠平均分为四组（每组6只）、对照组、AA（38.27 mg/kg体重）组、RJ（150 mg/kg体重）+AA组和RJ（300 mg/kg体重）+AA组。10天后采集血液和大脑样本，以评估血液学和生化参数，并检查组织病理学和免疫组织化学。AA的给药增加了丙二醛（MDA）的水平，降低了血液学参数、超氧化物歧化酶（SOD）、还原型谷胱甘肽（GSH）、脑源性神经营养因子（BDNF）、神经递质（血清素、多巴胺和乙酰胆碱）和裂解的胱天蛋白酶-3的水平，并增加了对脑组织的损伤。同时，RJ改善了AA诱导的血液学参数、氧化应激参数（MDA、SOD和GSH）、BDNF、神经递质、裂解的胱天蛋白酶-3和脑组织损伤的水平。研究表明，RJ对AA引起的血液学改变和神经毒性具有保护作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of chemical neuroanatomy 医学-神经科学

CiteScore

4.50

自引率

3.60%

发文量

审稿时长

62 days

期刊介绍： The Journal of Chemical Neuroanatomy publishes scientific reports relating the functional and biochemical aspects of the nervous system with its microanatomical organization. The scope of the journal concentrates on reports which combine microanatomical, biochemical, pharmacological and behavioural approaches. Papers should offer original data correlating the morphology of the nervous system (the brain and spinal cord in particular) with its biochemistry. The Journal of Chemical Neuroanatomy is particularly interested in publishing important studies performed with up-to-date methodology utilizing sensitive chemical microassays, hybridoma technology, immunocytochemistry, in situ hybridization and receptor radioautography, to name a few examples. The Journal of Chemical Neuroanatomy is the natural vehicle for integrated studies utilizing these approaches. The articles will be selected by the editorial board and invited reviewers on the basis of their excellence and potential contribution to this field of neurosciences. Both in vivo and in vitro integrated studies in chemical neuroanatomy are appropriate subjects of interest to the journal. These studies should relate only to vertebrate species with particular emphasis on the mammalian and primate nervous systems.