Assessing the causal association between dietary vitamin intake and lymphoma risk: a Mendelian randomisation study.

IF 3.5 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

International Journal of Food Sciences and Nutrition Pub Date : 2024-02-01 Epub Date: 2023-11-07 DOI:10.1080/09637486.2023.2278420

Mingming Zhou, Junfen Xia, Xiaolin Chen, Tiantian Wu, Kedi Xu, Yuanlin Zou, Shaobo Zhang, Pengxia Guo, Haoqing Cheng, Saba Fida, Chunhua Song

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引用次数: 0

Abstract

Observational studies of diet-related vitamins and lymphoma risk results were inconsistent. Our study aimed to estimate the causality between dietary vitamin intake and lymphoma through a Mendelian randomisation (MR) study. We enrolled dietary-related retinol, vitamin C, vitamin E, vitamin B6 and vitamin B12 as exposures of interest, with Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) as the outcome. The causal effects were estimated using inverse variance weighting (IVW), MR-Egger regression analysis and weighted median, supplemented by sensitivity analyses. The results revealed that genetically predicted dietary vitamin B12 intake was associated with a reduced HL risk (OR = 0.22, 95% CI 0.05-0.91, p = 0.036). The Q test did not reveal heterogeneity, the MR-Egger test showed no significant intercepts, and the leave-one-out (LOO) analysis did not discover any SNP that affect the results. No causal relationship about dietary vitamin intake on the NHL risk was observed.

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评估膳食维生素摄入与淋巴瘤风险之间的因果关系：一项孟德尔随机化研究。

饮食相关维生素和淋巴瘤风险的观察研究结果不一致。我们的研究旨在通过孟德尔随机化（MR）研究来估计饮食维生素摄入与淋巴瘤之间的因果关系。我们将饮食相关的视黄醇、维生素C、维生素E、维生素B6和维生素B12作为感兴趣的暴露，以霍奇金淋巴瘤（HL）和非霍奇金淋巴瘤（NHL）为结果。因果效应使用逆方差加权（IVW）、MR-Egger回归分析和加权中位数进行估计，并辅以敏感性分析。结果显示，基因预测的膳食维生素B12摄入与HL风险降低有关（OR = 0.22，95%置信区间0.05-0.91，p = 0.036）。Q检验没有显示异质性，MR Egger检验没有显示显著的截距，留一（LOO）分析没有发现任何影响结果的SNP。未观察到饮食维生素摄入与NHL风险之间的因果关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Food Sciences and Nutrition 工程技术-食品科技

CiteScore

7.50

自引率

2.60%

发文量

审稿时长

1 months

期刊介绍： The primary aim of International Journal of Food Sciences and Nutrition is to integrate food science with nutrition. Improvement of knowledge in human nutrition should always be the final objective of submitted research. It''s an international, peer-reviewed journal which publishes high quality, original research contributions to scientific knowledge. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.