The Potential Predicting Value of D-Dimer to Fibrinogen Ratio on Functional Outcome at 1 Year after Acute Ischemic Stroke: A Longitudinal Study.

IF 3.1 3区医学 Q3 GERIATRICS & GERONTOLOGY

Gerontology Pub Date : 2024-01-01 Epub Date: 2023-11-03 DOI:10.1159/000534768

Qingxia Lin, Dongdong Zhou, Yifan Cheng, Chunxue Wu, Binbin Deng

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引用次数: 0

Abstract

Introduction: Previous studies have suggested that the D-dimer to fibrinogen ratio (DD/Fg) could be a potential predictor for deep vein thrombosis, pulmonary embolism, and stroke severity. However, the association between plasma DD/Fg and functional outcome following acute ischemic stroke (AIS) has been unclear.

Methods: Our study followed the STROBE guideline and used a prospective cohort design to investigate this association. A total of 454 patients with AIS were enrolled consecutively in our study, and the National Institute of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS) were assessed for stroke severity and functional outcome, respectively.

Results: We found a significant difference in DD/Fg values between the three groups based on NIHSS scores at admission. Specifically, the DD/Fg values were higher in the poor functional outcome group (mRS score of 2-6) compared to the favorable functional outcome group (mRS score of 0-1) at the 1-year follow-up (p < 0.001). Additionally, the DD/Fg values were independently associated with poor functional prognosis at 1 year following the onset of stroke, even after adjusting for potential confounders (OR 9.21, 95% CI, 3.68-23.02, p < 0.001).

Conclusions: Our findings suggest that DD/Fg values at admission may serve as risk predictors for poor functional outcomes in patients with AIS 1 year after the stroke.

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D-二聚体与纤维蛋白原比值对急性缺血性卒中后1年功能转归的潜在预测价值：一项纵向研究。

先前的研究表明，D-二聚体与纤维蛋白原的比值（DD/Fg）可能是深静脉血栓形成、肺栓塞和中风严重程度的潜在预测指标。然而，血浆DD/Fg与急性缺血性卒中（AIS）后功能结果之间的关系尚不清楚。我们的研究遵循了STROBE指南，并使用前瞻性队列设计来调查这种关联。招募AIS患者，分别使用美国国立卫生研究所卒中量表（NIHSS）和改良兰金量表（mRS）评估卒中严重程度和功能结果。根据入院时的NIHSS评分，我们发现三组之间的DD/Fg值存在显著差异。具体而言，在1年的随访中，功能不良组（mRS评分2-6）的DD/Fg值高于功能良好组（mRS评分0-1）（P<0.001）。此外，在中风发作后1年，DD/Fg与功能不良预后独立相关，即使在校正了潜在的混杂因素后（OR 9.21，95%CI，3.68-23.02，P

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来源期刊

Gerontology 医学-老年医学

CiteScore

6.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： In view of the ever-increasing fraction of elderly people, understanding the mechanisms of aging and age-related diseases has become a matter of urgent necessity. ''Gerontology'', the oldest journal in the field, responds to this need by drawing topical contributions from multiple disciplines to support the fundamental goals of extending active life and enhancing its quality. The range of papers is classified into four sections. In the Clinical Section, the aetiology, pathogenesis, prevention and treatment of agerelated diseases are discussed from a gerontological rather than a geriatric viewpoint. The Experimental Section contains up-to-date contributions from basic gerontological research. Papers dealing with behavioural development and related topics are placed in the Behavioural Science Section. Basic aspects of regeneration in different experimental biological systems as well as in the context of medical applications are dealt with in a special section that also contains information on technological advances for the elderly. Providing a primary source of high-quality papers covering all aspects of aging in humans and animals, ''Gerontology'' serves as an ideal information tool for all readers interested in the topic of aging from a broad perspective.