Late Relapse in Neuroblastoma: Case Report and Review of the Literature.

IF 1.3 Q3 PEDIATRICS
Rejin Kebudi, Begum Koc, Banu Oflaz Sozmen
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引用次数: 0

Abstract

Background: Neuroblastoma is the most common extra-cranial solid tumor in children. The survival rate of relapsed/refractory neuroblastoma is dismal. Late recurrence may occur rarely.

Case presentation: We have, herein, presented a case with stage IV neuroblastoma who relapsed after 11 years and had a subsequent relapse after 15 years from the initial diagnosis, and reviewed cases with late relapsed (after >5 years) neuroblastoma in the literature. The case presented with recurrent disease at the T7 vertebra after 11 years from the initial diagnosis. The patient received surgery, chemotherapy, MIBG treatment, and antiGD2 combined with chemotherapy, and had a further local recurrence in the paravertebral area of the removed T7 vertebra after three years. The patient was operated, received anti-GD2 combined with chemotherapy, and is still alive with no symptoms for 19 months after the last relapse.

Conclusion: There is not a well-established treatment regimen for the majority of these patients. MIBG treatment and antiGD2 combined with chemotherapy may be promising options for relapsed/ refractory neuroblastoma.

神经母细胞瘤的晚期复发:病例报告和文献复习。
背景:神经母细胞瘤是儿童最常见的颅外实体瘤。复发/难治性神经母细胞瘤的生存率令人沮丧。晚期复发可能很少发生。病例介绍:我们在本文中介绍了一例IV期神经母细胞瘤,从最初诊断起11年后复发,15年后再次复发,并回顾了文献中晚期复发(5年以上)的神经母细胞癌病例。该病例自最初诊断起11年后出现T7椎骨的复发性疾病。患者接受了手术、化疗、MIBG治疗和抗GD2联合化疗,三年后切除的T7椎骨的椎旁区域再次局部复发。该患者接受了手术,接受了抗GD2联合化疗,在最后一次复发后的19个月内仍然存活,没有任何症状。结论:对于这些患者中的大多数,没有一个完善的治疗方案。MIBG治疗和抗GD2联合化疗可能是治疗复发/难治性神经母细胞瘤的有希望的选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.30
自引率
0.00%
发文量
66
期刊介绍: Current Pediatric Reviews publishes frontier reviews on all the latest advances in pediatric medicine. The journal’s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians in pediatric medicine.
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