WITHDRAWN: Analysis of the Efficacy of Drilling Decompression Autologous Bone Marrow and Allogeneic Bone Grafting in the Treatment of HIV-positive Patients with Early Osteonecrosis of the Femoral Head

IF 0.8 4区医学 Q4 IMMUNOLOGY

Current HIV Research Pub Date : 2023-11-03 DOI:10.2174/011570162X253808231025111220

Li Shengtao, Wang Jie, Ma Rui, Zhao Changsong, Pu Yu, He Min, Gao Zhengrong, Quan Xuemin, Zhang Qiang

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Abstract

The article has been withdrawn at the request of the author of the journal Current HIV Research (CHIVR).

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused. The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

Bentham science disclaimer: It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.

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钻孔减压自体骨髓和异体骨移植治疗HIV阳性早期股骨头坏死患者的疗效分析。

目的：探讨钻孔减压自体骨髓和异体骨移植治疗HIV阳性股骨头坏死的疗效。方法：回顾性分析自2015年10月以来采用钻孔减压自体骨髓和同种异体骨移植治疗的40例（44髋）早期股骨头坏死患者，其中20例（24髋）为HIV阳性早期股骨头缺血性坏死患者，男16例，女4例，年龄22-43岁，平均39.6±10.18岁，同期20例（20髋）HIV阴性的早期股骨头坏死患者，男13例，女7例，年龄48-78岁，平均63.50±7.94岁为阴性对照。术前记录所有患者的一般信息，包括ARCO分期、Harris评分、VAS评分、血液学指标（包括CD4+T淋巴细胞计数）和HIV病毒载量。所有患者均通过对坏死区域进行钻孔和减压，用同种异体骨收获自体髂骨骨髓，并通过减压通道进行骨移植。患者在术后6、12和24个月定期随访，此后每年随访一次，通过回顾髋关节的正面和侧面X光、CT或MRI观察坏死股骨头的修复情况，并统计和比较两组髋关节的并发症和功能恢复情况。结果：对所有患者进行了随访，HIV阳性组的ARCO分期为I期2髋、IIA期6髋、IIB期8髋、IIC期6髋和III期2髋，随访时间为12～60个月，平均24.6个月。阴性对照组ARCO I期3髋，IIA期7髋，IIB期5髋，IIC期3髋和III期2髋，随访时间13-62个月，平均24.8个月。两组髋关节Harris评分和VAS评分在术后6个月较术前均有明显改善（P<0.05），阳性组髋关节术后2年Harris评分与术后6月比较差异有统计学意义，但术后2年VAS评分与术后6个月比较无统计学意义。在阴性组中，术后2年髋关节的Harris评分和VAS评分与术后6个月髋关节的评分相比没有统计学显著差异。阳性组髋关节骨密度从术后开始就有持续增加的趋势（P<0.05）。在术后2年的随访中，阴性组和阳性组之间除了Harris评分和VAS评分外，没有统计学意义（P<0.05），术后随访2年，两组患者髋关节功能恢复良好，围术期和随访期均未发生血管、神经损伤、骨折等并发症，住院期间未发生切口感染、肺部感染等并发症。结论：对早期HIV阳性股骨头坏死患者钻孔减压去除股骨头坏死区，进行自体骨髓和同种异体骨移植，可有效阻止HIV阳性患者股骨头坏死的进展，延缓关节置换术的关节成形术，促进股骨头修复，是早期HIV阳性股骨头坏死患者安全有效的治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current HIV Research 医学-病毒学

CiteScore

1.90

自引率

10.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Current HIV Research covers all the latest and outstanding developments of HIV research by publishing original research, review articles and guest edited thematic issues. The novel pioneering work in the basic and clinical fields on all areas of HIV research covers: virus replication and gene expression, HIV assembly, virus-cell interaction, viral pathogenesis, epidemiology and transmission, anti-retroviral therapy and adherence, drug discovery, the latest developments in HIV/AIDS vaccines and animal models, mechanisms and interactions with AIDS related diseases, social and public health issues related to HIV disease, and prevention of viral infection. Periodically, the journal invites guest editors to devote an issue on a particular area of HIV research of great interest that increases our understanding of the virus and its complex interaction with the host.