Emerging Role of Non-collagenous Bone Proteins as Osteokines in Extraosseous Tissues.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-01-01 DOI:10.2174/0113892037268414231017074054

Kenda Jawich, Rana Hadakie, Souhaib Jamal, Rana Habeeb, Sahar Al Fahoum, Alberto Ferlin, Luca De Toni

{"title":"Emerging Role of Non-collagenous Bone Proteins as Osteokines in Extraosseous Tissues.","authors":"Kenda Jawich, Rana Hadakie, Souhaib Jamal, Rana Habeeb, Sahar Al Fahoum, Alberto Ferlin, Luca De Toni","doi":"10.2174/0113892037268414231017074054","DOIUrl":null,"url":null,"abstract":"<p><p>Bone is a unique tissue, composed of various types of cells embedded in a calcified extracellular matrix (ECM), whose dynamic structure consists of organic and inorganic compounds produced by bone cells. The main inorganic component is represented by hydroxyapatite, whilst the organic ECM is primarily made up of type I collagen and non-collagenous proteins. These proteins play an important role in bone homeostasis, calcium regulation, and maintenance of the hematopoietic niche. Recent advances in bone biology have highlighted the importance of specific bone proteins, named \"osteokines\", possessing endocrine functions and exerting effects on nonosseous tissues. Accordingly, osteokines have been found to act as growth factors, cell receptors, and adhesion molecules, thus modifying the view of bone from a static tissue fulfilling mobility to an endocrine organ itself. Since bone is involved in a paracrine and endocrine cross-talk with other tissues, a better understanding of bone secretome and the systemic roles of osteokines is expected to provide benefits in multiple topics: such as identification of novel biomarkers and the development of new therapeutic strategies. The present review discusses in detail the known osseous and extraosseous effects of these proteins and the possible respective clinical and therapeutic significance.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.2174/0113892037268414231017074054","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

Bone is a unique tissue, composed of various types of cells embedded in a calcified extracellular matrix (ECM), whose dynamic structure consists of organic and inorganic compounds produced by bone cells. The main inorganic component is represented by hydroxyapatite, whilst the organic ECM is primarily made up of type I collagen and non-collagenous proteins. These proteins play an important role in bone homeostasis, calcium regulation, and maintenance of the hematopoietic niche. Recent advances in bone biology have highlighted the importance of specific bone proteins, named "osteokines", possessing endocrine functions and exerting effects on nonosseous tissues. Accordingly, osteokines have been found to act as growth factors, cell receptors, and adhesion molecules, thus modifying the view of bone from a static tissue fulfilling mobility to an endocrine organ itself. Since bone is involved in a paracrine and endocrine cross-talk with other tissues, a better understanding of bone secretome and the systemic roles of osteokines is expected to provide benefits in multiple topics: such as identification of novel biomarkers and the development of new therapeutic strategies. The present review discusses in detail the known osseous and extraosseous effects of these proteins and the possible respective clinical and therapeutic significance.

查看原文本刊更多论文

非胶原骨蛋白作为骨因子在骨外组织中的新作用。

骨是一种独特的组织，由嵌入钙化细胞外基质（ECM）中的各种类型的细胞组成，其动态结构由骨细胞产生的有机和无机化合物组成。主要无机成分以羟基磷灰石为代表，而有机ECM主要由I型胶原蛋白和非胶原蛋白组成。这些蛋白质在骨稳态、钙调节和维持造血小生境中发挥着重要作用。骨生物学的最新进展突出了被称为“骨因子”的特定骨蛋白的重要性，该蛋白具有内分泌功能并对非骨组织产生作用。因此，骨因子已被发现充当生长因子、细胞受体和粘附分子，从而改变了骨从静止组织向内分泌器官本身迁移的观点。由于骨骼与其他组织存在旁分泌和内分泌串扰，因此更好地了解骨骼分泌组和骨因子的全身作用有望在多个领域提供益处：例如识别新的生物标志物和开发新的治疗策略。本综述详细讨论了这些蛋白质已知的骨和骨外作用，以及可能的各自临床和治疗意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.