Perinatal Outcome in Congenital Diaphragmatic Hernia (CDH): A Single-Center Experience.

IF 0.7 Q4 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynecology of India Pub Date : 2023-10-01 Epub Date: 2023-08-24 DOI:10.1007/s13224-023-01796-2

Anubhuti Rana, K Aparna Sharma, Vivek Kumar, Priyanka Chaudhary, Anu Thukral, Sandeep Agarwala, Vatsla Dadhwal

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引用次数: 0

Abstract

Objective: To study the perinatal outcome in fetuses diagnosed with congenital diaphragmatic hernia (CDH).

Methods: Thirty-two pregnant women with antenatal diagnosis of CDH in fetus, who delivered between 2018 and 2021, were included in the study. Postnatally eventration of diaphragm was diagnosed in 3 neonates and were excluded.

Results: The median gestational age at diagnosis was 23 weeks (IQR: 216-261 weeks). The mean O/E LHR was 34.88 ± 9.03%, and the O/E LHR was significantly lower in fetuses who did not survive (40.81 ± 4.25 vs 31.26 ± 9.33; p = 0.0037). On ROC analysis, at a cutoff of ≤ 32.93, O/E LHR had a specificity of 100% with a sensitivity of 72.22% in predicting mortality. Cases with liver herniation were not significantly different between survivors versus non-survivors. The overall survival rate was 37.93%, and the leading cause of death was severe persistent pulmonary hypertension.

Conclusion: O/E LHR can predict mortality in neonates with antenatal diagnosis of CDH. The presence of pulmonary hypertension was the leading cause of death in these neonates.

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先天性膈疝（CDH）的围产期结局：单中心经验。

目的：研究被诊断为先天性膈疝（CDH）的胎儿的围产期结局。3名新生儿被诊断为产后膈肌事件，并被排除在外。结果：诊断时的中位胎龄为23周（IQR:216-261周）。平均O/E LHR为34.88 ± 9.03%，未存活胎儿的O/E LHR显著降低（40.81 ± 4.25对31.26 ± 9.33；p = 0.0037）。在ROC分析中 ≤ O/E LHR预测死亡率的特异性为100%，敏感性为72.22%。存活者和非存活者之间的肝突出病例没有显著差异。总生存率为37.93%，死亡的主要原因是严重的持续性肺动脉高压。结论：O/E LHR可预测产前诊断为CDH的新生儿死亡率。肺动脉高压是这些新生儿死亡的主要原因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Obstetrics and Gynecology of India OBSTETRICS & GYNECOLOGY-

CiteScore

1.30

自引率

0.00%

发文量

124

期刊介绍： Journal of Obstetrics and Gynecology of India (JOGI) is the official journal of the Federation of Obstetrics and Gynecology Societies of India (FOGSI). This is a peer- reviewed journal and features articles pertaining to the field of obstetrics and gynecology. The Journal is published six times a year on a bimonthly basis. Articles contributed by clinicians involved in patient care and research, and basic science researchers are considered. It publishes clinical and basic research of all aspects of obstetrics and gynecology, community obstetrics and family welfare and subspecialty subjects including gynecological endoscopy, infertility, oncology and ultrasonography, provided they have scientific merit and represent an important advance in knowledge. The journal believes in diversity and welcomes and encourages relevant contributions from world over. The types of articles published are: · Original Article· Case Report · Instrumentation and Techniques · Short Commentary · Correspondence (Letter to the Editor) · Pictorial Essay