INTERRELATION BETWEEN PREOPERATIVE TESTS, INTRAOPERATIVE FINDINGS AND OUTCOMES OF 99M-TECHNETIUM-SESTAMIBI SCAN IN PRIMARY HYPERPARATHYROIDISM.

IF 0.7 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM
Acta Endocrinologica-Bucharest Pub Date : 2023-04-01 Epub Date: 2023-10-27 DOI:10.4183/aeb.2023.208
M Kostek, N Aygun, M T Unlu, M Uludag
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引用次数: 0

Abstract

Context: Primary hyperparathyroidism is one of the most common endocrinological disorder and surgery of parathyroid glands is the main therapy of this disease. Minimally invasive surgery is getting more prominent in these days and its success in parathyroid surgery mostly depends on accuracy of the localization studies.

Objective: The aim of this study is to understand the relationship between preoperative biochemical tests, intraoperative findings and Technetium-99m-methoxyisobutylisonitrile (MIBI) scan results.

Design: Retrospective clinical study.

Subjects and methods: A total of 185 patients, who have been diagnosed with primary hyperparathyroidism (PHPT) and operated between January, 2010 and October, 2018, were included to the study. Patients with less than 6 months of follow up are excluded from the study.

Results: Patients were divided into two groups according to their scintigraphy results; with positive scintigraphy findings as group 1 (n:135) and negative scintigraphy findings as group 2 (n:50). Mean preoperative serum parathyroid hormone (PTH) values were significantly different between the two groups (p<0.02). Mean preoperative serum calcium, creatinine, magnesium, phosphorus, alkaline phosphatase, 25-OH Vitamin D3 levels of both groups were analyzed and there were no statistical differences between the two groups considering these parameters. Also, mean diameter and mean volume of parathyroid adenomas were significantly higher in group 1 (2.1±1.0 cm vs. 1.55±0.72 cm, respectively, p<0.0001; 2.66±5.35 cm3 vs. 1±1.9 cm3, respectively, p<0.0001). Optimal cut-off values of parathyroid adenoma diameter for MIBI scan positivity were 1.55 cm, parathyroid volume for MIBI scan positivity were 0.48 cm3, preoperative serum PTH for MIBI scan positivity were 124.5 ng/L.

Conclusions: Preoperative serum PTH levels, diameter and volume of adenomas might be helpful for the prediction of MIBI scan accuracy and possible need of another localization studies.

原发性甲状旁腺功能亢进症的术前检查、术中表现和99M-倍他美比扫描结果之间的相关性。
背景:原发性甲状旁腺功能亢进是最常见的内分泌疾病之一,甲状旁腺手术是该疾病的主要治疗方法。微创手术在这些天变得越来越突出,它在甲状旁腺手术中的成功主要取决于定位研究的准确性。目的:本研究旨在了解术前生化检查、术中表现与99m-甲氧基异丁基异腈锝(MIBI)扫描结果之间的关系。设计:回顾性临床研究。受试者和方法:共有185名患者被诊断为原发性甲状旁腺功能亢进症(PHPT),并在2010年1月至2018年10月期间接受了手术。随访时间少于6个月的患者被排除在研究之外。结果:根据闪烁扫描结果将患者分为两组;其中阳性闪烁扫描结果为第1组(n:135),阴性闪烁扫描发现为第2组(n:50)。两组患者术前血清甲状旁腺激素(PTH)的平均值存在显著差异(pvs.1.55±0.72cm,p3vs.1±1.9cm3,p3,术前血清PTH对MIBI扫描阳性率为124.5ng/L。结论:术前血清甲状旁腺激素水平、腺瘤直径和体积可能有助于预测MIBI扫描的准确性,并可能需要另一项定位研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Acta Endocrinologica-Bucharest
Acta Endocrinologica-Bucharest 医学-内分泌学与代谢
CiteScore
1.30
自引率
20.00%
发文量
53
审稿时长
6-12 weeks
期刊介绍: Acta Endocrinologica (Buc) is an international journal covering the fields of basic and clinical Endocrinology, Neuroendocrinology, Reproductive Medicine, Chronobiology, Human Ethology published quarterly Acta Endocrinologica (Buc) is the official international journal of the Romanian Society for Endocrinology. It continues the former Romanian Journal of Endocrinology
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