Sperm in the Mammalian Female Reproductive Tract: Surfing Through the Tract to Try to Beat the Odds.

IF 8.7 1区 农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE
David J Miller
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引用次数: 0

Abstract

Mammalian sperm are deposited in the vagina or the cervix/uterus at coitus or at artificial insemination, and the fertilizing sperm move through the female reproductive tract to the ampulla of the oviduct, the site of fertilization. But the destination of most sperm is not the oviduct. Most sperm are carried by retrograde fluid flow to the vagina, are phagocytosed, and/or do not pass barriers on the pathway to the oviduct. The sperm that reach the site of fertilization are the exceptions and winners of one of the most stringent selection processes in nature. This review discusses the challenges sperm encounter and how the few sperm that reach the site of fertilization overcome them. The sperm that reach the goal must navigate viscoelastic fluid, swim vigorously and cooperatively along the walls of the female tract, avoid the innate immune system, and respond to potential cues to direct their movement.

哺乳动物雌性生殖道中的精子:在生殖道中漫游,试图打破几率。
哺乳动物的精子在性交或人工授精时沉积在阴道或宫颈/子宫中,受精精子通过女性生殖道到达输卵管壶腹,即受精部位。但大多数精子的目的地不是输卵管。大多数精子通过逆行液体流到阴道,被吞噬,和/或不通过通往输卵管的通道上的屏障。到达受精部位的精子是自然界中最严格的选择过程之一的例外和赢家。这篇综述讨论了精子遇到的挑战,以及到达受精位点的少数精子是如何克服这些挑战的。达到目标的精子必须在粘弹性流体中穿行,沿着雌性生殖道壁有力而协作地游动,避开先天免疫系统,并对潜在的线索做出反应,以指导它们的运动。《动物生物科学年度评论》第12卷预计最终在线出版日期为2024年2月。请参阅http://www.annualreviews.org/page/journal/pubdates用于修订估算。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Annual Review of Animal Biosciences
Annual Review of Animal Biosciences BIOTECHNOLOGY & APPLIED MICROBIOLOGY-ZOOLOGY
CiteScore
21.30
自引率
0.80%
发文量
31
期刊介绍: The Annual Review of Animal Biosciences is primarily dedicated to the fields of biotechnology, genetics, genomics, and breeding, with a special focus on veterinary medicine. This includes veterinary pathobiology, infectious diseases and vaccine development, and conservation and zoo biology. The publication aims to address the needs of scientists studying both wild and domesticated animal species, veterinarians, conservation biologists, and geneticists.
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