Improved Muscle Mass and Function With Protein Supplementation in Older Adults With Sarcopenia: A Meta-Analysis.

IF 2.1 Q1 REHABILITATION

Annals of Rehabilitation Medicine-ARM Pub Date : 2023-10-01 Epub Date: 2023-10-23 DOI:10.5535/arm.23076

Hyo Eun Kwon, Nayeon Ko, Doyoung Yuk, Seo Won Choi, Seong-Eun Koh

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Abstract

Objective: : To systematically review the effects of protein supplementation in older adults with sarcopenia.

Methods: : A systematic literature search was conducted in PubMed, Cochrane Library, and Embase databases until May 2023. The inclusion criteria were as follows: (1) randomized controlled trials with a quantitative study design; (2) studies with a study group of older adults with sarcopenia; (3) studies comparing muscle mass, muscle strength, and performance of older adults with sarcopenia after protein supplementation; and (4) studies published up to May 2023.

Results: : Six retrospective comparative studies, including 715 patients, met the inclusion criteria. The nutritional supplementation group exhibited significant improvement in appendicular skeletal muscle mass (standardized mean difference [SMD]=0.41; 95% confidence interval [CI], 0.24-0.58; p<0.001; I²=1%), while handgrip strength (SMD=0.37; 95% CI, -0.32-1.07; p=0.29; I²=94%) and Short Physical Performance Battery (SPPB) (SMD=0.35; 95% CI, -0.47-1.18; p=0.40; I²=94%) showed a tendency for improvement.

Conclusion: : Nutritional supplementation with protein increased appendicular muscle mass in older adults with sarcopenia and improved handgrip strength and SPPB scores.

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补充蛋白质改善老年肌肉萎缩患者的肌肉质量和功能：荟萃分析。

目的：系统评价补充蛋白质治疗老年少肌症的疗效。方法：在PubMed、Cochrane Library和Embase数据库中进行系统的文献检索，直到2023年5月。纳入标准如下：（1）采用定量研究设计的随机对照试验；（2）对患有少肌症的老年人研究组的研究；（3）比较补充蛋白质后老年少肌症患者的肌肉质量、肌肉力量和表现的研究；以及（4）截至2023年5月发表的研究。结果：6项回顾性比较研究，包括715名患者，符合纳入标准。营养补充组的阑尾骨骼肌质量显著改善（标准化平均差[SMD]=0.41；95%置信区间[CI]，0.24-0.58；p2=1%），而握力（SMD=0.37；95%CI，-0.32-1.07；p=0.29；I2=94%）和短体力电池（SPPB）（SMD=0.35；95%CI，-0.47-1.18；p=0.40；I2=90%）则有改善的趋势。结论：补充蛋白质营养可增加老年少肌症患者的阑尾肌肉质量，并改善握力和SPPB评分。

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