From Traditional Medicine to Advanced Therapeutics: The Renaissance of Phyto-nano Interventions in Psoriasis.

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Rajneesh Semele, Sonam Grewal, Manish Kumar Jeengar, Thakur Gurjeet Singh, Rajan Swami
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引用次数: 0

Abstract

Psoriasis is an autoimmune systemic chronic inflammatory disease that exhibits characteristic detrimental effects on the skin, often leading to infections or comorbid conditions. The multifaceted nature of psoriasis has made it very challenging to treat, especially with current chemotherapy options. Therefore, it is essential to consider phytoconstituents as novel alternatives. However, despite demonstrating higher anti-inflammatory, anti-psoriasis, and immunomodulatory potential, their clinical usage is hindered due to their poor physicochemical properties. To address these drawbacks, nanoparticulate drug delivery systems have been developed, helping to achieve better permeation of phytoconstituents through topical administration. This has breathed new life into traditional systems of medicine, particularly in the context of treating psoriasis. In this current review, we present a detailed, comprehensive, and up-to-date analysis of the literature, which will contribute to affirming the clinical role of phyto-nano interventions against psoriasis.

从传统医学到高级治疗:植物纳米介入治疗银屑病的复兴。
银屑病是一种自身免疫系统性慢性炎症性疾病,对皮肤表现出特有的有害影响,通常会导致感染或合并症。银屑病的多面性使其治疗极具挑战性,尤其是在目前的化疗方案下。因此,有必要考虑将植物成分作为新的替代品。然而,尽管表现出更高的抗炎、抗银屑病和免疫调节潜力,但由于其较差的物理化学性质,其临床应用受到阻碍。为了解决这些缺点,已经开发了纳米颗粒药物递送系统,有助于通过局部给药实现植物成分的更好渗透。这为传统医学体系注入了新的活力,尤其是在治疗银屑病的背景下。在这篇综述中,我们对文献进行了详细、全面和最新的分析,这将有助于肯定植物纳米干预措施对银屑病的临床作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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