The mechanisms and roles of mitochondrial dynamics in C. elegans

IF 6.2 2区生物学 Q1 CELL BIOLOGY

Seminars in cell & developmental biology Pub Date : 2023-10-31 DOI:10.1016/j.semcdb.2023.10.006

Daniel Campbell, Steven Zuryn

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Abstract

If mitochondria are the powerhouses of the cell, then mitochondrial dynamics are the power grid that regulates how that energy output is directed and maintained in response to unique physiological demands. Fission and fusion dynamics are highly regulated processes that fine-tune the mitochondrial networks of cells to enable appropriate responses to intrinsic and extrinsic stimuli, thereby maintaining cellular and organismal homeostasis. These dynamics shape many aspects of an organism’s healthspan including development, longevity, stress resistance, immunity, and response to disease. In this review, we discuss the latest findings regarding the mechanisms and roles of mitochondrial dynamics by focussing on the nematode Caenorhabditis elegans. Whole live-animal studies in C. elegans have enabled a true organismal-level understanding of the impact that mitochondrial dynamics play in homeostasis over a lifetime.

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秀丽隐杆线虫线粒体动力学的机制和作用。

如果线粒体是细胞的动力库，那么线粒体动力学就是调节能量输出如何被引导和维持以响应独特生理需求的电网。裂变和融合动力学是高度调节的过程，可以微调细胞的线粒体网络，从而对内在和外在刺激做出适当的反应，从而维持细胞和生物体的稳态。这些动态影响了生物体健康寿命的许多方面，包括发育、寿命、抗压能力、免疫力和对疾病的反应。在这篇综述中，我们通过关注线虫秀丽隐杆线虫来讨论线粒体动力学的机制和作用的最新发现。对秀丽隐杆线虫的活体动物研究使我们能够真正从生物体层面了解线粒体动力学在一生中对体内平衡的影响。

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来源期刊

Seminars in cell & developmental biology 生物-发育生物学

CiteScore

15.10

自引率

1.40%

发文量

310

审稿时长

9.1 weeks

期刊介绍： Seminars in Cell and Developmental Biology is a review journal dedicated to keeping scientists informed of developments in the field of molecular cell and developmental biology, on a topic by topic basis. Each issue is thematic in approach, devoted to an important topic of interest to cell and developmental biologists, focusing on the latest advances and their specific implications. The aim of each issue is to provide a coordinated, readable, and lively review of a selected area, published rapidly to ensure currency.