Chemical composition and biological activities of essential oil from Grewia bulot leaves.

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2024-12-01 Epub Date: 2023-11-01 DOI:10.1080/14786419.2023.2275739

Ty Viet Pham, Duc Viet Ho, Anh Tuan Le, Y Duy Ngo, Nhan Thanh Thi Dang, Thang Quoc Le, Bao Chi Nguyen

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Abstract

This study focused on the chemical composition and biological activities of the essential oil derived from Grewia bulot, a plant species known for its medicinal properties. The analysis of Grewia bulot essential oil revealed the presence of 78 constituents. The major compounds were α-cadinol (13.5%), 1,8-cineole (12.7%), 1,10-di-epi-cubenol (9.8%), epi-α-cadinol (6.7%), (E,E)-α-farnesene (5.9%), (E)-citral (4.0%), selin-11-en-4-α-ol (4.0%), citronellol isobutanoate (3.9%), and geranic acid (3.7%). The essential oil exhibited promising antioxidant potential with an IC₅₀ value of 452.65 ± 28.40 µg/mL in DPPH model. This oil did not show NO production inhibitory effect in RAW 264.7 cells. In addition, the essential oil exhibited significant cytotoxicity against KB, Hep-G2, MCF-7, and SK-LU-1 cancer cell lines, with IC₅₀ values ranging from 44.04 ± 1.47 to 74.20 ± 3.71 μg/mL.

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葛叶精油的化学成分和生物活性。

本研究的重点是从以药用特性闻名的植物Grewia bulot中提取的精油的化学成分和生物活性。Grewia bulot精油的分析揭示了78种成分的存在。主要化合物为α-cadinol（13.5%）、1,8-桉叶醇（12.7%）、1,10-二-异-苯甲醇（9.8%）、表观-α-cadiol（6.7%）、（E，E）-α-法尼烯（5.9%）、柠檬醛（4.0%）、selin-11-en-4-α-醇（4.0%）、异丁醇香茅醇（3.9%）和香叶酸（3.7%）。该精油具有良好的抗氧化潜力，IC50值为452.65 ± 28.40 DPPH模型中为µg/mL。该油在RAW 264.7细胞中没有显示出NO产生抑制作用。此外，精油对KB、Hep-G2、MCF-7和SK-LU-1癌症细胞系表现出显著的细胞毒性，IC50值在44.04之间 ± 1.47至74.20 ± 3.71 μg/mL。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.