BSHI and BTS UK guideline on the detection of alloantibodies in solid organ (and islet) transplantation

IF 2.3 4区 医学 Q3 GENETICS & HEREDITY
Richard Battle, Deborah Pritchard, Sarah Peacock, Catherine Hastie, Judith Worthington, Sue Jordan, Jennifer A McCaughlan, Martin Barnardo, Rebecca Cope, Claire Collins, Natalia Diaz-Burlinson, Carla Rosser, Luke Foster, Delordson Kallon, Olivia Shaw, David Briggs, David Turner, Arthi Anand, Arash Akbarzad-Yousefi, Deborah Sage
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引用次数: 1

Abstract

Solid organ transplantation represents the best (and in many cases only) treatment option for patients with end-stage organ failure. The effectiveness and functioning life of these transplants has improved each decade due to surgical and clinical advances, and accurate histocompatibility assessment. Patient exposure to alloantigen from another individual is a common occurrence and takes place through pregnancies, blood transfusions or previous transplantation. Such exposure to alloantigen's can lead to the formation of circulating alloreactive antibodies which can be deleterious to solid organ transplant outcome. The purpose of these guidelines is to update to the previous BSHI/BTS guidelines 2016 on the relevance, assessment, and management of alloantibodies within solid organ transplantation.

BSHI和BTS UK关于在实体器官(和胰岛)移植中检测同种异体抗体的指南。
实体器官移植是终末期器官衰竭患者的最佳(在许多情况下也是唯一)治疗选择。由于外科和临床的进步以及准确的组织相容性评估,这些移植的有效性和功能寿命每十年都在提高。患者接触来自另一个人的同种异体抗原是常见的,发生在怀孕、输血或之前的移植中。这种暴露于同种异体抗原可导致循环同种异体反应性抗体的形成,这可能对实体器官移植结果有害。本指南旨在更新2016年BSHI/BTS关于实体器官移植中同种异体抗体相关性、评估和管理的指南。
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来源期刊
CiteScore
4.70
自引率
0.00%
发文量
48
审稿时长
6-12 weeks
期刊介绍: The International Journal of Immunogenetics (formerly European Journal of Immunogenetics) publishes original contributions on the genetic control of components of the immune system and their interactions in both humans and experimental animals. The term ''genetic'' is taken in its broadest sense to include studies at the evolutionary, molecular, chromosomal functional and population levels in both health and disease. Examples are: -studies of blood groups and other surface antigens- cell interactions and immune response- receptors, antibodies, complement components and cytokines- polymorphism- evolution of the organisation, control and function of immune system components- anthropology and disease associations- the genetics of immune-related disease: allergy, autoimmunity, immunodeficiency and other immune pathologies- All papers are seen by at least two independent referees and only papers of the highest quality are accepted.
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