Association of BDNF risk variant and dorsolateral cortical thickness with long-term treatment response to valproate in type I bipolar disorder: An exploratory study

IF 1.6 3区 医学 Q3 GENETICS & HEREDITY
Alejandra Monserrat Rodríguez-Ramírez, Valente Cedillo-Ríos, Marco Antonio Sanabrais-Jiménez, Claudia Becerra-Palars, Sandra Hernández-Muñoz, Hiram Ortega-Ortíz, Beatriz Camarena-Medellin
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引用次数: 0

Abstract

Valproate is among the most prescribed drugs for bipolar disorder; however, 87% of patients do not report full long-term treatment response (LTTR) to this medication. One of valproate's suggested mechanisms of action involves the brain-derived neurotrophic factor (BDNF), expressed in the brain areas regulating emotions, such as the prefrontal cortex. Nonetheless, data about the role of BDNF in LTTR and its implications in the structure of the dorsolateral prefrontal cortex (dlPFC) is scarce. We explore the association of BDNF variants and dorsolateral cortical thickness (CT) with LTTR to valproate in bipolar disorder type I (BDI). Twenty-eight BDI patients were genotyped for BDNF polymorphisms rs1519480, rs6265, and rs7124442, and T1-weighted 3D brain scans were acquired. LTTR to valproate was evaluated with Alda's scale. A logistic regression analysis was conducted to evaluate LTTR according to BDNF genotypes and CT. We evaluated CT differences by genotypes with analysis of covariance. LTTR was associated with BDNF rs1519480 and right dlPFC thickness. Insufficient responders with the CC genotype had thicker right dlPFC than TC and TT genotypes. Full responders reported thicker right dlPFC in TC and TT genotypes. In conclusion, different patterns of CT related to BDNF genotypes were identified, suggesting a potential biomarker of LTTR to valproate in our population.

BDNF风险变异和背外侧皮质厚度与I型双相情感障碍患者丙戊酸钠长期治疗反应的相关性:一项探索性研究。
丙戊酸钠是治疗双相情感障碍最常用的药物之一;然而,87%的患者没有报告对该药物的完全长期治疗反应(LTTR)。丙戊酸钠提出的作用机制之一涉及脑源性神经营养因子(BDNF),该因子在大脑调节情绪的区域表达,如前额叶皮层。尽管如此,关于BDNF在LTTR中的作用及其在背外侧前额叶皮层(dlPFC)结构中的意义的数据很少。我们探讨了BDNF变异和背外侧皮质厚度(CT)与I型双相情感障碍(BDI)患者丙戊酸LTTR的关系。对28名BDI患者进行BDNF多态性rs1519480、rs6265和rs7124442的基因分型,并进行T1加权3D脑扫描。用Alda量表评估丙戊酸的LTTR。根据BDNF基因型和CT进行逻辑回归分析以评估LTTR。我们通过协方差分析评估基因型的CT差异。LTTR与BDNF rs1519480和右侧dlPFC厚度有关。CC基因型应答不足者的右dlPFC比TC和TT基因型更厚。完全应答者报告TC和TT基因型的右dlPFC较厚。总之,发现了与BDNF基因型相关的不同CT模式,这表明在我们的人群中,丙戊酸钠的LTTR是一个潜在的生物标志物。
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来源期刊
CiteScore
5.90
自引率
7.10%
发文量
40
审稿时长
4-8 weeks
期刊介绍: Neuropsychiatric Genetics, Part B of the American Journal of Medical Genetics (AJMG) , provides a forum for experimental and clinical investigations of the genetic mechanisms underlying neurologic and psychiatric disorders. It is a resource for novel genetics studies of the heritable nature of psychiatric and other nervous system disorders, characterized at the molecular, cellular or behavior levels. Neuropsychiatric Genetics publishes eight times per year.
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