An early clinical phenotype of necrotizing meningoencephalitis in the Pug reveals similarities to multiple sclerosis in humans.

IF 1.3 3区农林科学 Q2 VETERINARY SCIENCES

American journal of veterinary research Pub Date : 2023-11-06 Print Date: 2024-01-01 DOI:10.2460/ajvr.23.07.0164

Rebecca Windsor, Samuel Stewart, Matt Huentelman, Stefan Keller, Chand Khanna

引用次数: 0

Abstract

Necrotizing meningoencephalitis (NME) is a fatal neuroinflammatory disease that previously carried a uniformly grave prognosis. Our recent identification of a novel early form of NME in Pugs suggests that disease onset and progression are likely more insidious than previously recognized and provides new hope that early therapeutic intervention may halt disease progression and ultimately prevent or cure NME. This novel perspective also sheds new light on the clinical similarities to multiple sclerosis (MS) in humans and provides a rationale for cross-species translation. The history of recent scientific discoveries in NME and new parallels between MS and NME will be reviewed.

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Pug坏死性脑膜脑炎的早期临床表型显示与人类多发性硬化症相似。

坏死性脑膜脑炎（NME）是一种致命的神经炎症性疾病，以前预后一致严重。我们最近在Pugs中发现了一种新型的早期NME，这表明疾病的发作和进展可能比以前认识到的更为隐蔽，并为早期治疗干预可能阻止疾病进展并最终预防或治愈NME提供了新的希望。这一新颖的视角也为人类多发性硬化症（MS）的临床相似性提供了新的线索，并为跨物种翻译提供了理论依据。将回顾NME的最新科学发现的历史，以及MS和NME之间的新相似之处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American journal of veterinary research 农林科学-兽医学

CiteScore

1.70

自引率

10.00%

发文量

186

审稿时长

3 months

期刊介绍： The American Journal of Veterinary Research supports the collaborative exchange of information between researchers and clinicians by publishing novel research findings that bridge the gulf between basic research and clinical practice or that help to translate laboratory research and preclinical studies to the development of clinical trials and clinical practice. The journal welcomes submission of high-quality original studies and review articles in a wide range of scientific fields, including anatomy, anesthesiology, animal welfare, behavior, epidemiology, genetics, heredity, infectious disease, molecular biology, oncology, pharmacology, pathogenic mechanisms, physiology, surgery, theriogenology, toxicology, and vaccinology. Species of interest include production animals, companion animals, equids, exotic animals, birds, reptiles, and wild and marine animals. Reports of laboratory animal studies and studies involving the use of animals as experimental models of human diseases are considered only when the study results are of demonstrable benefit to the species used in the research or to another species of veterinary interest. Other fields of interest or animals species are not necessarily excluded from consideration, but such reports must focus on novel research findings. Submitted papers must make an original and substantial contribution to the veterinary medicine knowledge base; preliminary studies are not appropriate.