Platelet lifespan and mechanisms for clearance.

IF 3.1 3区医学 Q2 HEMATOLOGY

Current Opinion in Hematology Pub Date : 2024-01-01 Epub Date: 2023-10-30 DOI:10.1097/MOH.0000000000000792

Olga An, Carsten Deppermann

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引用次数: 0

Abstract

Purpose of review: Activated or aged platelets are removed from circulation under (patho)physiologic conditions, the exact mechanism of platelet clearance under such conditions remains unclear and are currently being investigated. This review focuses on recent findings and controversies regarding platelet clearance and the disruption of platelet life cycle.

Recent findings: The platelet life span is determined by glycosylation of platelet surface receptors with sialic acid. Recently, it was shown that platelet activation and granule release leads to desialylation of glycans and accelerated clearance of platelets under pathological conditions. This phenomenon was demonstrated to be a main reason for thrombocytopenia being a complication in several infections and immune disorders.

Summary: Although we have recently gained some insight into how aged platelets are cleared from circulation, we are still not seeing the full picture. Further investigations of the platelet clearance pathways under pathophysiologic conditions are needed as well as studies to unravel the connection between platelet clearance and platelet production.

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血小板寿命和清除机制。

综述目的：活化或老化的血小板在（病理）生理条件下从循环中清除，在这种条件下血小板清除的确切机制尚不清楚，目前正在研究中。这篇综述的重点是关于血小板清除和血小板生命周期破坏的最新发现和争议。最近的发现：血小板的寿命是由血小板表面受体与唾液酸的糖基化决定的。最近，研究表明，在病理条件下，血小板活化和颗粒释放会导致聚糖的去分析和血小板的加速清除。这种现象被证明是血小板减少症成为几种感染和免疫疾病并发症的主要原因。摘要：尽管我们最近对衰老血小板如何从循环中清除有了一些了解，但我们仍然没有看到全貌。需要进一步研究病理生理条件下的血小板清除途径，以及研究血小板清除和血小板生成之间的联系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Hematology 医学-血液学

CiteScore

6.60

自引率

3.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Current Opinion in Hematology is an easy-to-digest bimonthly journal covering the most interesting and important advances in the field of hematology. Its hand-picked selection of editors ensure the highest quality selection of unbiased review articles on themes from nine key subject areas, including myeloid biology, Vascular biology, hematopoiesis and erythroid system and its diseases.