Association Between Three Atopic Triad and Retinal Vein Occlusion Risk: A Nationwide Population-Based Study.

IF 1.7 4区 医学 Q3 OPHTHALMOLOGY
Ophthalmic epidemiology Pub Date : 2024-08-01 Epub Date: 2023-10-30 DOI:10.1080/09286586.2023.2276193
Seongho Kim, Bo Hee Kim, Kyungdo Han, Mingui Kong, Su Jeong Song
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引用次数: 0

Abstract

Purpose: To evaluate the association between three allergic diseases (allergic dermatitis, allergic rhinitis, and asthma) and the development of retinal vein occlusion (RVO), a major retinal disease that causes visual impairment.

Method: This study used data obtained from the Korean National Health Insurance Claims database between 2009 and 2018. The association between the three atopic triads (allergic dermatitis, allergic rhinitis, and asthma) and the occurrence of sight-threatening RVO, as determined by diagnostic and treatment codes, were analyzed. Multivariate adjusted Cox regression analysis was used to determine the hazard ratios (HRs) and 95% confidence intervals for RVO development in the presence of allergic disease.

Results: In this population-based study, 2,160,195 (54.6%) individuals were male, 1,794,968 (45.4%) were female, and 620,938 (15.7%) were diagnosed with allergic diseases. Patients with either asthma or allergic rhinitis had a greater risk of RVO (adjusted hazard ratio (aHR) = 1.101, 95% confidence interval [CI] = 1.029-1.178 for asthma; aHR = 1.181, 95% CI = 1.147-1.215 for allergic rhinitis) compared to those without asthma or allergic rhinitis; however, patients with atopic dermatitis did not show a significant association with RVO (aHR = 1.071, 95% CI = 0.889-1.290), after adjusting for other risk factors.

Conclusion: Our study revealed that allergic rhinitis, asthma, and coexisting multiple allergic conditions were associated with an increased risk of RVO. Thus, it may be advisable to suggest an ophthalmological examination for patients with allergies due to the increased possibility of the occurrence of retinal vascular disease.

三种特应性三联征与视网膜静脉闭塞风险的相关性:一项基于全国人群的研究。
目的:评估三种过敏性疾病(过敏性皮炎、过敏性鼻炎和哮喘)与视网膜静脉阻塞(RVO)发展之间的关系,RVO是一种导致视力障碍的主要视网膜疾病。方法:本研究使用了2009年至2018年间从韩国国民健康保险索赔数据库中获得的数据。根据诊断和治疗规范,分析了三种特应性三联征(过敏性皮炎、过敏性鼻炎和哮喘)与威胁视力的RVO发生之间的关系。使用多变量校正Cox回归分析来确定过敏性疾病情况下RVO发展的危险比(HR)和95%置信区间。结果:在这项基于人群的研究中,2160195人(54.6%)为男性,1794968人(45.4%)为女性,620938人(15.7%)被诊断为过敏性疾病。哮喘或过敏性鼻炎患者发生RVO的风险更大(调整后的危险比(aHR) = 1.101,95%置信区间[CI] = 1.029-1.178用于哮喘;aHR = 1.181195%CI = 1.147-1.215,用于过敏性鼻炎)与没有哮喘或过敏性鼻炎的患者相比;然而,特应性皮炎患者并没有表现出与RVO(aHR = 1.071,95%CI = 0.889-1.290)。结论:我们的研究表明,过敏性鼻炎、哮喘和共存的多种过敏性疾病与RVO的风险增加有关。因此,由于视网膜血管疾病发生的可能性增加,建议对过敏患者进行眼科检查。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Ophthalmic epidemiology
Ophthalmic epidemiology 医学-眼科学
CiteScore
3.70
自引率
5.60%
发文量
61
审稿时长
6-12 weeks
期刊介绍: Ophthalmic Epidemiology is dedicated to the publication of original research into eye and vision health in the fields of epidemiology, public health and the prevention of blindness. Ophthalmic Epidemiology publishes editorials, original research reports, systematic reviews and meta-analysis articles, brief communications and letters to the editor on all subjects related to ophthalmic epidemiology. A broad range of topics is suitable, such as: evaluating the risk of ocular diseases, general and specific study designs, screening program implementation and evaluation, eye health care access, delivery and outcomes, therapeutic efficacy or effectiveness, disease prognosis and quality of life, cost-benefit analysis, biostatistical theory and risk factor analysis. We are looking to expand our engagement with reports of international interest, including those regarding problems affecting developing countries, although reports from all over the world potentially are suitable. Clinical case reports, small case series (not enough for a cohort analysis) articles and animal research reports are not appropriate for this journal.
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