Diagnostic assessment of two-dimensional shear wave elastography in relation to dimethyl arginine levels in dogs with chronic kidney disease.

IF 1.5 3区农林科学 Q2 VETERINARY SCIENCES

Journal of Veterinary Science Pub Date : 2023-11-01 Epub Date: 2023-09-26 DOI:10.4142/jvs.23101

Hyun Cho, Seungwha Yang, Gukhyun Suh, Jihye Choi

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Abstract

Background: In veterinary medicine, previous studies regarding the diagnostic performance of shear wave elastography (SWE) in chronic kidney disease (CKD) are not consistent with each other. Moreover, there has been no study evaluating the relationship between symmetric dimethyl arginine (SDMA) concentration and renal shear wave velocity (SWV) using two-dimensional SWE (2D SWE) in dogs with CKD.

Objectives: This study aimed to evaluate the diagnostic capability of 2D SWE in dogs with CKD and to assess the relationship between renal SWV and SDMA concentration.

Methods: Dogs with healthy kidneys and dogs with CKD underwent 2D SWE and SDMA assay. Renal stiffness was estimated as renal SWV in m/s.

Results: SDMA concentration had a weak positive correlation with the left (r = 0.338, p = 0.022) and right renal SWV (r = 0.337, p = 0.044). Renal SWV was not significantly different between healthy kidney and CKD groups in the left (p = 0.085) and right (p = 0.171) kidneys.

Conclusions: 2D SWE may could not distinguish between dogs with healthy kidney and dogs with early stage of CKD, but it would be useful for assessing the serial change of renal function in dogs.

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二维剪切波弹性成像与慢性肾脏疾病犬二甲基精氨酸水平关系的诊断评估。

背景：在兽医学中，先前关于剪切波弹性成像（SWE）对慢性肾脏疾病（CKD）的诊断性能的研究并不一致。此外，还没有研究使用二维SWE（2D SWE）来评估CKD犬对称二甲基精氨酸（SDMA）浓度与肾脏剪切波速（SWV）之间的关系。方法：对肾脏健康的狗和CKD的狗进行2D SWE和SDMA测定。肾硬度估计为肾SWV，单位为m/s。结果：SDMA浓度与左肾（r=0.338，p=0.022）和右肾SWV（r=0.337，p=0.044）呈弱正相关。健康肾组和CKD组在左肾（p=0.085）和右肾脏（p=0.171）的肾SWV无显著差异。结论：2D SWE可能无法区分肾脏健康的狗和CKD早期的狗，但它有助于评估狗肾功能的一系列变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Veterinary Science 农林科学-兽医学

CiteScore

3.10

自引率

5.60%

发文量

审稿时长

1.3 months

期刊介绍： The Journal of Veterinary Science (J Vet Sci) is devoted to the advancement and dissemination of scientific knowledge concerning veterinary sciences and related academic disciplines. It is an international journal indexed in the Thomson Scientific Web of Science, SCI-EXPANDED, Sci Search, BIOSIS Previews, Biological Abstracts, Focus on: Veterinary Science & Medicine, Zoological Record, PubMed /MEDLINE, Index Medicus, Pubmed Central, CAB Abstracts / Index Veterinarius, EBSCO, AGRIS and AGRICOLA. This journal published in English by the Korean Society of Veterinary Science (KSVS) being distributed worldwide.