N6-Methyladenosine (m6A) Modification in Natural Immune Cell-Mediated Inflammatory Diseases.

IF 4.7 3区医学 Q2 IMMUNOLOGY

Journal of Innate Immunity Pub Date : 2023-01-01 Epub Date: 2023-10-30 DOI:10.1159/000534162

Yan Teng, Jin Yi, Junnian Chen, Lu Yang

引用次数: 0

Abstract

The post-transcriptional N6-methyladenosine (m6A) modification of RNA influences stability, transport, and translation with implications for various physiological and pathological processes. Immune cell development, differentiation, and activation are also thought to be regulated by m6A and affect host defense against pathogens and inflammatory response with impacts on infectious, neoplastic, autoimmune, cardiovascular, hepatic, and osteal diseases. The current review summarizes recent research on m6A in monocyte/macrophages, neutrophils, dendritic cells, natural killer cells, and microglia and gives insights into epigenetic modifications of the immune system and novel therapeutic strategies for immune-related diseases.

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天然免疫细胞介导的炎症性疾病中的N6-甲基腺苷（m6A）修饰。

RNA的转录后N6-甲基腺苷（m6A）修饰影响稳定性、转运和翻译，对各种生理和病理过程有影响。免疫细胞的发育、分化和激活也被认为受m6A的调节，并影响宿主对病原体的防御和炎症反应，对感染性、肿瘤性、自身免疫性、心血管、肝脏和骨骼疾病产生影响。本文综述了单核细胞/巨噬细胞、中性粒细胞、树突状细胞、自然杀伤细胞和小胶质细胞中m6A的最新研究，并深入了解了免疫系统的表观遗传学修饰和免疫相关疾病的新治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Innate Immunity 医学-免疫学

CiteScore

10.50

自引率

1.90%

发文量

审稿时长

7.5 months

期刊介绍： The ''Journal of Innate Immunity'' is a bimonthly journal covering all aspects within the area of innate immunity, including evolution of the immune system, molecular biology of cells involved in innate immunity, pattern recognition and signals of ‘danger’, microbial corruption, host response and inflammation, mucosal immunity, complement and coagulation, sepsis and septic shock, molecular genomics, and development of immunotherapies. The journal publishes original research articles, short communications, reviews, commentaries and letters to the editors. In addition to regular papers, some issues feature a special section with a thematic focus.