Assessing the Risk of Secondary Cancer Induction in Radiosensitive Organs During Trigeminal Neuralgia Treatment With Gamma Knife Radiosurgery: Impact of Extracranial Dose.

IF 2.3 4区医学 Q3 PHARMACOLOGY & PHARMACY

Dose-Response Pub Date : 2023-10-26 eCollection Date: 2023-10-01 DOI:10.1177/15593258231210432

Ghazale Geraily, Ali Ameri, Atefeh Mahmoudi, Mohadese Moafee, Javad Teymouri

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Abstract

Purpose: Gamma knife radiosurgery (GKRS) delivers high-dose external radiation to a small intracranial lesion. However, scattering and leaked radiation can deposit a portion of the dose outside the radiation field, which may pose a risk to radiation-sensitive patients, such as pregnant women. Trigeminal Neuralgia (TN) is treated with one of the highest GKRS doses (80-90 Gy). This study aimed to estimate the risk of secondary cancer induction in the uterus, ovaries, thyroid gland, and eyes of TN patients undergoing GKRS.

Methods: Radiation doses to the uterus, ovary, eyes, and thyroid gland were measured for 25 female TN patients, with a mean age of 35 years, utilizing Thermo Luminescent Dosimeters (TLD).

Results: The mean absorbed dose for the uterus, ovary, thyroid gland, and eyes were .63 ± .24, .471 ± .2, 8.26 ± 1.01, and 10.64 ± 1.08 cGy, respectively. Lifetime Attributable Risk (LAR) has been calculated using BEIR VII (2006) method. LAR for the uterus, ovary, and thyroid gland was 1, 2, and 23, respectively.

Conclusion: The results of this study and its comparison with standard values demonstrate that on average, mean doses to mentioned organs were smaller than their tolerance doses, and there is no limitation to treating patients suffering from TN by GK.

Abstract Image

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伽玛刀放射治疗三叉神经痛期间放射性敏感器官继发性癌症诱导的风险评估：颅外剂量的影响。

目的：伽玛刀放射外科（GKRS）为颅内小病变提供高剂量外照射。然而，散射和泄漏的辐射会将一部分剂量沉积在辐射场之外，这可能会对辐射敏感的患者（如孕妇）构成风险。三叉神经痛（TN）采用GKRS最高剂量之一（80-90Gy）进行治疗。本研究旨在评估接受GKRS的TN患者的子宫、卵巢、甲状腺和眼睛继发癌症诱导的风险，甲状腺和眼睛分别为.63±.24、.471±.2、8.26±1.01和10.64±1.08 cGy。使用BEIR VII（2006）方法计算了寿命归因风险。子宫、卵巢和甲状腺的LAR分别为1、2和23。结论：本研究的结果及其与标准值的比较表明，平均而言，上述器官的平均剂量小于其耐受剂量，GK治疗TN患者没有限制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dose-Response PHARMACOLOGY & PHARMACY-RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

CiteScore

4.90

自引率

4.00%

发文量

140

审稿时长

>12 weeks

期刊介绍： Dose-Response is an open access peer-reviewed online journal publishing original findings and commentaries on the occurrence of dose-response relationships across a broad range of disciplines. Particular interest focuses on experimental evidence providing mechanistic understanding of nonlinear dose-response relationships.