Epigenetic Clocks: In Aging-Related and Complex Diseases.

IF 1.7 4区生物学 Q4 CELL BIOLOGY

Cytogenetic and Genome Research Pub Date : 2023-01-01 Epub Date: 2023-10-28 DOI:10.1159/000534561

Katia Margiotti, Francesca Monaco, Marco Fabiani, Alvaro Mesoraca, Claudio Giorlandino

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引用次数: 0

Abstract

Background: There is evidence that complex diseases and mortality are associated with DNA methylation and age acceleration. Numerous epigenetic clocks, including Horvath, Hannum, DNA PhenoAge, DNA GrimAge, and Dunedin Pace of Aging Methylation, continue to be developed in this young scientific field. The most well-known epigenetic clocks are presented here, along with information about how they relate to chronic disease.

Summary: We examined all the literature until January 2023, investigating associations between measures of age acceleration and complex and age-related diseases. We focused on the scientific literature and research that are most strongly associated with epigenetic clocks and that have shown promise as biomarkers for obesity, cardiovascular illness, type 2 diabetes, and neurodegenerative disease.

Key messages: Understanding the complex interactions between accelerated epigenetic clocks and chronic diseases may have significant effects on both the early diagnosis of disease and health promotion. Additionally, there is a lot of interest in developing treatment plans that can delay the onset of illnesses or, at the very least, alter the underlying causes of such disorders.

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表观遗传学时钟：在与AGING相关和复杂的疾病中。

有证据表明，复杂的疾病和死亡率与DNA甲基化（DNAm）和年龄加速有关。许多表观遗传学时钟，包括Horvath、Hannum、DNA PhenoAge、DNA GrimAge和DunedinPoAm，继续在这个年轻的科学领域发展。这里介绍了最著名的表观遗传学时钟，以及它们与慢性病的关系。我们检查了截至2023年1月的所有文献，调查了年龄加速指标与复杂和年龄相关疾病之间的关系。我们专注于与表观遗传学时钟最密切相关的科学文献和研究，这些文献和研究已显示出作为肥胖、心血管疾病、2型糖尿病和神经退行性疾病的生物标志物的前景。了解加速的表观遗传学时钟与慢性病之间的复杂相互作用可能对疾病的早期诊断和健康促进都有重大影响。此外，人们对制定治疗计划很感兴趣，这些计划可以延缓疾病的发作，或者至少可以改变这些疾病的根本原因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cytogenetic and Genome Research 生物-细胞生物学

CiteScore

3.10

自引率

5.90%

发文量

审稿时长

1 months

期刊介绍： During the last decades, ''Cytogenetic and Genome Research'' has been the leading forum for original reports and reviews in human and animal cytogenetics, including molecular, clinical and comparative cytogenetics. In recent years, most of its papers have centered on genome research, including gene cloning and sequencing, gene mapping, gene regulation and expression, cancer genetics, comparative genetics, gene linkage and related areas. The journal also publishes key papers on chromosome aberrations in somatic, meiotic and malignant cells. Its scope has expanded to include studies on invertebrate and plant cytogenetics and genomics. Also featured are the vast majority of the reports of the International Workshops on Human Chromosome Mapping, the reports of international human and animal chromosome nomenclature committees, and proceedings of the American and European cytogenetic conferences and other events. In addition to regular issues, the journal has been publishing since 2002 a series of topical issues on a broad variety of themes from cytogenetic and genome research.